TABLE 2.
Parameter values from the PK-PD model fitted to mice
| Parametera | Mean | Median | SD |
|---|---|---|---|
| Ka (h−1) | 11.312 | 14.895 | 6.594 |
| SCL/F (liters/h) | 0.039 | 0.026 | 0.031 |
| Vc/F (liters) | 0.051 | 0.069 | 0.033 |
| Kcp (h−1) | 15.741 | 15.404 | 6.806 |
| Kpc (h−1) | 16.997 | 16.915 | 5.962 |
| Kcb (h−1) | 3.446 | 0.594 | 4.709 |
| Kbc (h−1) | 0.056 | 0.056 | 0.030 |
| Kgmax (log10 CFU/g/h) | 0.107 | 0.098 | 0.025 |
| Hg | 10.338 | 5.096 | 9.782 |
| C50g (liters/h) | 2.036 | 1.681 | 1.517 |
| POPMAX (CFU/g) | 982,934,669.178 | 427,055,621.187 | 2,281,967,059.602 |
| IC (CFU/g) | 102.255 | 116.462 | 60.966 |
| Vb/F (liters) | 0.277 | 0.146 | 0.335 |
a
Ka is the first-order rate constant collecting the gut and the central compartment; SCL/F is the apparent clearance of flubendazole from the central compartment; Vc/F and Vb/F are the apparent volumes of the central compartment and brain, respectively; Kcp, Kpc, Kcb, and Kbc are the first-order intercompartmental rate constants; and Kgmax is the maximal rate of cryptococcal growth. POPMAX is the maximum theoretical fungal density. C50g is the concentrations of flubendazole that induce half-maximal effects on growth. Hg is the slope function for the effect of flubendazole on growth. IC is the density of Cryptococcus immediately postinoculation.