TABLE 2.
Variability in gentamicin dosing recommendations for two typical patientsa
| Guideline | Dosing regimen (mg/kg; h)b |
|||
|---|---|---|---|---|
| Patient 1 (GA = 30 wks) |
Patient 2 (GA = 38 wks) |
|||
| PNA, 2 days; wt, 1.3 kg | PNA, 15 days; wt, 1.5 kg | PNA, 2 days; wt, 3.0 kg | PNA, 15 days; wt, 3.3 kg | |
| Nelson | 5; 48 | 4; 24 | 4; 24 | 4; 24 |
| BNFc | 5; 36 | 5; 24 | 5; 36 | 5; 24 |
| Shann | 5; 36 | 5; 24 | 5; 24 | 6; 24 |
| Lexicomp | 4.5; 36 | 5; 36 | 4; 24 | 5; 24 |
| Center 1 | 5; 48 | 5; 36 | 4; 24 | 4; 24 |
| Center 3 | 4–5; 36 | 4–5; 24 | 4–5; 24 | 4–5; 24 |
| Center 6 | 4.5; 36 | 4; 24 | 4; 24 | 4; 24 |
| Center 7 | 5; 24–48 | 5; 24–48 | 5; 24–48 | 5; 24–48 |
a
See Table 1, footnote a, for abbreviation definitions.
b
Dosing regimens are expressed as follows: amount (mg/kg); interval (h). Hence, “5; 48” indicates “5 mg/kg administered every 48 h.”