TABLE 3.
Meropenem urine PK parameters
| Cohort/dosea and treatment | n | Median (range) amt (mg) excreted as intact meropenem |
Median (range) % of dose excreted as intact meropenem |
Median (range) renal clearance (liter/h) |
|||
|---|---|---|---|---|---|---|---|
| Single dose (collected over 48 h) | Multiple dose (collected over 24 h) | Single dose (collected over 48 h) | Multiple dose (collected over 24 h) | Single dose | Multiple dose | ||
| 1/1,000:250 | |||||||
| Meropenem alone | 32 | 562.8 (358.1–687.4) | 603.5 (503.6–710.8) | 56.3 (35.8–68.7) | 60.4 (50.4–71.1) | 11.4 (5.4–14.9) | 12.6 (8.7–17.9) |
| Combination | 16 | 608.8 (521.3–695.6) | 635.5 (458.4–1299) | 60.9 (52.1–69.6) | 63.6 (45.8–129.9) | 10.5 (8.7–13.1) | 13.5 (10.1–28.0) |
| 2/1,000:1,000 | |||||||
| Meropenem alone | 13 | 534.4 (421.8–613.7) | 545.7 (462.2–629.3) | 53.4 (42.2–61.4) | 54.6 (46.2–62.9) | 8.9 (6.8–11.1) | 10.8 (10.2–11.3) |
| Combination | 10 | 529.4 (437.3–581.2) | 537.8 (423.4–685.4) | 52.9 (43.7–58.1) | 53.8 (42.3–68.5) | 8.1 (6.6–9.7) | 10.4 (8.6–10.8) |
| 3/1,000:1,500 | |||||||
| Meropenem alone | 19 | 558.4 (470.9–619.6) | 606.1 (600.5–611.9) | 55.8 (47.1–62.0) | 60.6 (60.1–61.2) | 8.5 (6.7–10.2) | 10.1 (6.6–11.0) |
| Combination | 14 | 499.7 (346.4–650.1) | 538.6 (376.9–888.5) | 50.0 (34.6–65.0) | 53.9 (37.7–88.8) | 6.9 (4.6–11.4) | 8.7 (5.5–14.5) |
| 4/1,000:2,000 | |||||||
| Meropenem alone | 19 | 563.4 (409.2–734.9) | 564.6 (540.7–602.8) | 56.3 (40.9–73.5) | 56.5 (54.1–60.3) | 10.9 (6.8–15.1) | 11.2 (9.8–12.4) |
| Combination | 14 | 486.6 (384.9–567.4) | 512.4 (88.9–645.9) | 48.7 (38.5–56.7) | 51.2 (8.9–64.6) | 8.6 (7.0–11.6) | 10.5 (1.9–14.1) |
| 5/2,000:2,000 | |||||||
| Meropenem alone | 20 | 1,069 (723.0–1,345) | 1,084 (913.5–1,343) | 53.4 (36.2–67.2) | 54.2 (45.7–67.2) | 8.0 (4.6–11.9) | 8.9 (6.1–10.0) |
| Combination | 16 | 937.8 (844.8–1,191) | 1,120 (829.4–1,202) | 46.9 (42.2–59.6) | 56.0 (41.50–60.1) | 6.9 (5.2–8.9) | 8.1 (5.8–9.4) |
a
Expressed as meropenem (mg): vaborbactam (mg).