TABLE 4.
Vaborbactam urine PK parameters
| Cohort/dosea and treatment | n | Median (range) amt (mg) excreted as intact vaborbactam |
Median (range) % of dose excreted as intact vaborbactam |
Median (range) renal clearance (liter/h) |
|||
|---|---|---|---|---|---|---|---|
| Single dose (collected over 48 h) | Multiple dose (collected over 24 h) | Single dose (collected over 48 h) | Multiple dose (collected over 24 h) | Single dose | Multiple dose | ||
| 1/1,000:250 | |||||||
| Vaborbactam alone | 40 | 206.2 (124.3–356.5) | 219.1 (49.3–256.6) | 82.5 (49.7–142.6) | 87.6 (19.7–102.6) | 12.2 (6.3–23.7) | 13.1 (3.3–19.7) |
| Combination | 16 | 212.1 (200.1–2,824) | 231.1 (196.9–588.2) | 84.84 (80.0–1,130) | 95.2 (78.8–235.3) | 11.8 (10.1–189.8) | 17.6 (12.5–44.9) |
| 2/1,000:1,000 | |||||||
| Vaborbactam alone | 5 | 810.0 (789.7–922.2) | 81.0 (79.0–92.2) | 11.0 (8.8–14.9) | |||
| Combination | 10 | 830.9 (773.4–682.5) | 858.2 (757.9–930.3) | 83.1 (77.3–86.3) | 85.8 (75.8–93.0) | 10.3 (8.6–12.7) | 11.5 (10.6–16.1) |
| 3/1,000:1,500 | |||||||
| Vaborbactam alone | 7 | 1,233 (1,010–1,400) | 82.2 (67.3–93.3) | 9.8 (8.5–14.0) | |||
| Combination | 14 | 1,128 (858.9–1,324) | 1,284 (1,015–1,728) | 75.2 (57.3–88.3) | 85.6 (67.6–115.2) | 8.6 (6.8–11.0) | 12.3 (8.5–15.6) |
| 4/1,000:2,000 | |||||||
| Vaborbactam alone | 7 | 1,744 (1,591–1,825) | 87.2 (79.6–91.3) | 14.1 (12.2–15.4) | |||
| Combination | 14 | 1,718 (1,341–1,781) | 1,697 (318.9–1,821) | 85.9 (67.1–89.1) | 84.8 (16.0–91.1) | 12.6 (10.5–15.3) | 13.9 (2.8–18.5) |
| 5/2,000:2,000 | |||||||
| Vaborbactam alone | 8 | 1,785 (1,347–2,070) | 89.3 (67.4–103.5) | 10.8 (8.6–14.4) | |||
| Combination | 16 | 1,548 (1,388–1,622) | 1,715 (1,502–1,926) | 77.4 (69.4–81.1) | 85.8 (75.1–96.3) | 10.0 (6.9–11.4) | 8.6 (6.5–12.1) |
a
Expressed as meropenem (mg): vaborbactam (mg).