. 2018 Mar 27;62(4):e01647-17. doi: 10.1128/AAC.01647-17

TABLE 3.

Comparison of results from analyses of observed and simulated trough concentrations

Trough type	AUC₂₄/trough achievement^a	Trough concn
Trough type	AUC₂₄/trough achievement^a	All troughs (mg/liter)	8–8.9 mg/liter	10–14.9 mg/liter	15–20 mg/liter
Observed	Minimum trough range predictive of AUC₂₄ > 400	8–8.9
	No. of troughs	184	13	59	17
	% troughs achieving AUC₂₄ > 400	76	92	98	100
	Median AUC₂₄ (range)		464 (370–619)	542 (398–690)	610 (553–803)
Simulated	Minimum trough range predictive of AUC₂₄ > 400	8–8.9
	No. of troughs	160,000	9,833	40,570	25,954
	% troughs achieving AUC₂₄ > 400	77	97	100	100
	Median AUC₂₄ (range)		446 (372–546)	543 (403–716)	666 (530–841)

AUC₂₄, steady state area under the concentration-time curve over the past 24 h.