TABLE 2.
Comparative MICs of omadacycline and comparator agents tested against anaerobic dog and cart bite isolatesa
| Organism (no. of isolates) and drug | MIC range | MIC50 | MIC90 |
|---|---|---|---|
| Bacteroides pyogenes (10) | |||
| Omadacycline | 0.06–0.25 | 0.25 | 0.25 |
| Tigecycline | 0.125–0.5 | 0.25 | 0.5 |
| Tetracycline | 0.25–16 | 0.25 | 16 |
| Minocycline | ≤0.03–2 | ≤0.03 | 2 |
| Amoxicillin-clavulanate | 0.06–1 | 0.06 | 1 |
| Eikenella corrodens (10) | |||
| Omadacycline | 4–16 | 8 | 16 |
| Tigecycline | 2–8 | 4 | 8 |
| Tetracycline | 2–4 | 4 | 4 |
| Minocycline | 0.5–4 | 1 | 2 |
| Amoxicillin-clavulanate | 1–2 | 2 | 2 |
| Fusobacterium sp. (10)b | |||
| Omadacycline | 0.25–1 | 0.25 | 0.25 |
| Tigecycline | ≤0.03–0.125 | 0.06 | 0.125 |
| Tetracycline | 0.06–0.5 | 0.125 | 0.5 |
| Minocycline | ≤0.03–0.125 | ≤0.03 | 0.125 |
| Amoxicillin-clavulanate | 0.125–4 | 0.125 | 2 |
| Porphyromonas sp. (12)c | |||
| Omadacycline | 0.06–0.5 | 0.06 | 0.06 |
| Tigecycline | ≤0.03–0.25 | ≤0.03 | ≤0.03 |
| Tetracycline | 0.06–0.125 | 0.06 | 0.125 |
| Minocycline | ≤0.03–≤0.03 | ≤0.03 | ≤0.03 |
| Amoxicillin-clavulanate | ≤0.03–0.5 | ≤0.03 | 0.125 |
| Prevotella heparinolytica (10) | |||
| Omadacycline | 0.125–0.125 | 0.125 | 0.125 |
| Tigecycline | 0.06–0.125 | 0.06 | 0.125 |
| Tetracycline | 0.06–8 | 0.125 | 8 |
| Minocycline | ≤0.03–4 | ≤0.03 | 4 |
| Amoxicillin-clavulanate | 0.125–0.5 | 0.25 | 0.5 |
| Prevotella sp. (10)d | |||
| Omadacycline | 0.125–1 | 0.25 | 0.25 |
| Tigecycline | ≤0.03–1 | 0.25 | 0.25 |
| Tetracycline | 0.06–16 | 0.25 | 16 |
| Minocycline | ≤0.03–8 | ≤0.03 | 4 |
| Amoxicillin-clavulanate | 0.06–1 | 0.125 | 1 |
a
Values are in micrograms per milliliter.
b
Fusobacterium canifelinum (n = 5) and F. nucleatum (n = 5).
c
P. cangingivalis (n = 2), P. canoris (n = 2), P. cansulci (n = 2), P. circumdentaria (n = 1), P. gingivalis (n = 2), P. gulae (n = 2), and P. macaccae (n = 1).
d
P. bivia (n = 2), P. denticola (n = 1), P. intermedia/nigrescens (n = 1), P. loescheii (n = 1), P. melaninogenica (n = 1), P. enoeca (n = 1), Prevotella species (n = 1), and P. zoogleoformans (n = 2).