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Venn diagram of circulating miRNAs detected in the elderly T2D cohort and in the R and NR subcohorts. Patients were classified as responders (R) or nonresponders (NR) based on their glycemic control status after 15 months of treatment with metformin + sitagliptin (t 15). Venn diagrams show the number of miRNAs detected in NR and R plasma samples collected (a) before the start of combined therapy (baseline, t 0) and (b) at t 15 and (c) at both t 0 and t 15.
