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Role of GRP78 in OGD/reoxygenation-induced NSCs. (a) Abolished upregulation of cleaved caspase-3 by OGD+R in GRP78 knocked-down NSCs. (b) Attenuated cellular injury by OGD+R in GRP78 knocked-down NSCs. ∗∗P < 0.01 was considered to be significantly different between Neg-siRNA-control and Neg-siRNA-OGD+R groups; #P < 0.05 was considered to be significantly different between GRP78-siRNA-control versus GRP78-siRNA-OGD+R groups. n = 3.
