Table 6.
AUCs with statistical differences and optimal cut-offs of tumor markers and ROMA for the differentiation of stage I FIGO malignant adnexal tumors and epithelial ovarian cancer from nonmalignant adnexal tumors.
| Diagnostic test | Stage I FIGO malignant adnexal tumors versus nonmalignant adnexal tumors | Epithelial ovarian cancer versus nonmalignant adnexal tumors | ||||
|---|---|---|---|---|---|---|
| AUC (95% CI) | p value | Optimal cut-off | AUC (95% CI) | p value | Optimal cut-off | |
| HE4 | 0.802 (0.695–0.910) | <0.001 | 56 | 0.928 (0.882–0.974) | <0.001 | 72.1 |
| CA125 | 0.559 (0.388–0.731) | 0.427 | — | 0.858 (0.781–0.935) | <0.001 | 54.4 |
| ROMA | 0.789 (0.679–0.898) | <0.001 | 10.5 | 0.929 (0.882–0.976) | <0.001 | 18.3 |
AUC: area under the curve; FIGO: Fédération Internationale de Gynécologie et d'Obstétrique; CI: confidence interval; ROMA: Risk of Ovarian Malignancy Algorithm.