Table 1.

Expression of otoconial genes by RNA-Seq analysis (as fragments per kilobase per million reads, or FPKM) of epithelial cells from the utricle and saccule (U+S), as compared to the cochlea (Co), in C57BL/6J mice at age P0.

Product Type	Gene	U+S	Co	U+S/Co
Constituent proteins	Oc90	10405.5	7672.4	1.4
	Otol1	296.9	3.3	91.4
	Sparc	4059.5	8192.5	0.5
	Sparcl1	665.7	1154.2	0.6
	Spp1 (splice variant 1)	392.0	815.7	0.5
	Spp1 (splice variant 2)	35.3	83.2	0.4
	Dmp1	2.4	0.3	9.4
	Lum	105.1	1167.8	0.1
	Fmod	14.1	2.8	5.1
	Omd	3.7	1.0	3.8
	Ahsg	0.2	0.0	N/A
Regulatory proteins	Otop1	20.4	0.1	183.5
	Nox3	25.0	0.5	48.8
	Cyba	230.2	114.6	2.0
	Noxo1	78.4	14.4	5.4
	Noxa1 (splice variant 1)	1.5	0.0	3068.6
	Noxa1 (splice variant 2)	0.0	1.2	0.0
	Slc26a4	16.8	1.5	10.9
	Slc30a4	3.2	1.2	2.8
	Pldn	24.6	8.6	2.9
	Atg4a	7.7	4.9	1.6
	Atg4b	30.4	13.1	2.3
	Atg4c	13.4	3.9	3.4
	Atg4d	9.1	1.1	8.0
	Atp2b2	6.6	1.5	4.3
	Car2	172.9	142.2	1.2
	Car3	1403.4	4716.3	0.3
	Car7	73.6	1.3	55.0
	Car12	91.0	11.7	7.8
	Car13	24.3	8.1	3.0
	Car14	87.7	77.4	1.1
	Trpv2	0.9	3.3	0.3
	Trpv4	24.1	6.3	3.8
	Trpv6	2.0	0.1	33.2
Anchoring proteins	Otog	86.5	6.6	13.0
	Otogl	10.8	4.7	2.3
	Otoa	229.1	98.1	2.3
	Tecta	103.3	265.5	0.4
	Tectb	620.8	728.7	0.9

Note: Otol1, Lum, Fmod and Omd are also anchoring proteins, and Tecta is also an otoconial component protein. The full names of the genes are listed in Supplementary Table 1.