. Author manuscript; available in PMC: 2018 Apr 24.

Published in final edited form as: Am J Geriatr Psychiatry. 2016 Jul 21;24(11):1040–1050. doi: 10.1016/j.jagp.2016.07.015

Table 4.

Proposed deficits in emotion regulation in late-life GAD

Domain	Deficit	Functional connectivity findings
Emotion Generation (Worry Induction)	Excessive attribution of negative affective value to worry statements	Greater Insula-OFC connectivity during worry induction in pre-treatment GAD (compared with non-anxious participants and with post-treatment GAD)
Emotion Generation (Worry Induction)	Excessive attribution of threat	Greater BNST-Insula connectivity during worry induction in GAD
Emotion Regulation (Worry reappraisal)	Failure to reappraise worry	Lower insula-prefrontal connectivity during worry reappraisal in GAD
		Lower prefrontal connectivity (BA46-BA10/BA9) in GAD during worry reappraisal
		Greater prefrontal connectivity in post-treatment GAD during worry reappraisal
	Rigid executive network control	Similar nodes connected during both induction and reappraisal of worry in GAD
	Increased stress response during reappraisal	Greater BNST-subgenual cingulate connectivity in pre-treatment GAD during worry induction
	Increased stress response during reappraisal	Greater PVN-Amygdala connectivity in pre-treatment GAD during worry reappraisal