Skip to main content
. Author manuscript; available in PMC: 2019 Apr 12.
Published in final edited form as: J Med Chem. 2018 Mar 26;61(7):2694–2706. doi: 10.1021/acs.jmedchem.7b01282

Figure 1.

Figure 1

Top: Chemical structure of 1. Bottom: Overlay of 1(teal): DCN1 (electrostatic potential surface) (PDB: 6BG5)1 and UBE2MNAc (magenta): DCN1 (PDB: 3TDU) X-ray co-crystal structures, highlighting regions targeted for optimization1.