Fig. 1. Tau amyloid fibers. (A) TEM image of tau amyloid fibers, scale bar: 200 nm. Typical spherical oligomers are shown with white arrows. (B) 2D-graph of CD-MS measurements performed on tau amyloid fiber sample. (C) Mass distribution drawn from (B). The two populations (high mass and low mass) have been distinguished thanks to their different time of flight. The mass distributions are histogrammed using a given bin-size (5 MDa). Each bar represents the number of measured ions whose masses correspond to the mass range of the bin.