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ADAR3 translocates transiently from the cytoplasm to the nucleus upon neuronal activation. (A) ADAR3 immunohistochemistry in SH-SY5Y cells shows mostly diffuse ADAR3 staining in the cytoplasm at 0 h. (B) At 3 h post KCl-mediated activation, ADAR3 protein shows mostly nuclear localization (C) but by 6 h ADAR3 is seen to be returning to a more cytoplasmic pattern.
