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. 2018 Apr 17;9:180. doi: 10.3389/fphar.2018.00180

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Copyright © 2018 Du, Wang, Liu, Zhang, Xu, Xu, Sun and Sun.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Schematic representation of AsC-mediated cardioprotective effect against H/R injury. AsC inhibited ER stress-dependent apoptotic pathways though attenuating PERK/eIF2α signal pathway in ER stress. This effect was mediated by the increase of HSP90 expression. 17-AAG and siRNA abolished the protective effect of AsC against H/R injury.