Table 2.
Incidence of stroke and stroke subtype and multivariate Cox proportional hazards regression analysis measured hazard ratio for study cohort
| SRMD cohort |
Comparison cohort |
Crude HR (95% CI) | Adjusted HR (95% CI) | |||||
|---|---|---|---|---|---|---|---|---|
| Variable | Event | PYs | Rate | Event | PYs | Rate | ||
| All stroke | 70 | 2,236 | 31.31 | 87 | 10,332 | 8.42 | 5.02 (3.98–6.38)*** | 2.29 (1.42–3.80)*** |
| Hemorrhagic stroke | 14 | 2,236 | 6.26 | 6 | 10,332 | 0.58 | 6.76 (4.53–8.34)* | 4.25 (1.96–6.61)* |
| Ischemic stroke | 56 | 2,236 | 25.04 | 81 | 10,332 | 7.84 | 5.00 (4.31–5.61) ** | 2.04 (1.95–2.87)** |
| <45 years | ||||||||
| All stroke | 21 | 930 | 22.58 | 9 | 3,679 | 2.45 | 6.60 (6.12–7.80)*** | 4.03 (3.11–5.62)*** |
| Hemorrhagic stroke | 7 | 930 | 7.53 | 3 | 3,679 | 0.82 | 8.45 (7.14–8.69)** | 6.77 (4.88–7.64)* |
| Ischemic stroke | 14 | 930 | 15.05 | 6 | 3,679 | 1.63 | 6.57 (5.43–7.33)** | 3.92 (3.24–5.59)** |
| 45–64 years | ||||||||
| All stroke | 7 | 1,025 | 6.83 | 21 | 4,758 | 4.41 | 3.39 (3.70–4.46)*** | 1.07 (1.02–1.71)*** |
| Hemorrhagic stroke | 4 | 1,025 | 3.90 | 2 | 4,758 | 0.42 | 5.93 (3.27–7.54)** | 3.25 (1.11–4.87)* |
| Ischemic stroke | 3 | 1,025 | 2.93 | 19 | 4,758 | 3.99 | 3.07 (2.87–4.77)** | 1.04 (1.00–1.62)* |
| ≧65 years | ||||||||
| All stroke | 42 | 281 | 149.47 | 57 | 1,895 | 30.08 | 5.51 (3.30–6.21)*** | 2.64 (1.12–3.44)*** |
| Hemorrhagic stroke | 3 | 281 | 10.68 | 1 | 1,895 | 0.53 | 6.84 (4.37–9.01)*** | 4.27 (2.56–6.36)** |
| Ischemic stroke | 39 | 281 | 138.79 | 56 | 1,895 | 29.55 | 5.32 (4.75–6.00)*** | 2.11 (1.70–3.05)** |
| Male | ||||||||
| All stroke | 35 | 1,261 | 27.76 | 36 | 5,670 | 6.35 | 5.61 (4.21–6.86)*** | 2.98 (1.74–4.50)*** |
| Hemorrhagic stroke | 7 | 1,261 | 5.55 | 3 | 5,670 | 0.53 | 7.68 (4.07–8.49)** | 5.55 (2.10–6.82)* |
| Ischemic stroke | 28 | 1,261 | 22.20 | 33 | 5,670 | 5.82 | 5.51 (4.81–5.77)** | 2.74 (2.15–3.28)* |
| Female | ||||||||
| All stroke | 35 | 975 | 35.90 | 51 | 4,662 | 10.94 | 4.53 (2.46–19.42)*** | 1.94 (1.01–3.77)** |
| Hemorrhagic stroke | 7 | 975 | 7.18 | 3 | 4,662 | 0.64 | 6.38 (4.25–8.21)** | 3.69 (1.98–6.00)* |
| Ischemic stroke | 28 | 975 | 28.72 | 48 | 4,662 | 10.30 | 4.49 (3.15–5.06)*** | 1.82 (1.33–2.41)** |
Model adjusted for age, sex, hypertension, DM, IHD, hyperlipidemia, AF and OSA.
*
P < 0.05; **P < 0.01; ***P < 0.001.