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(A–C) Effect of mutations in CL and CH1 on antibody expression. The antibody concentration in culture supernatants of HEK293-6E was determined 5 days post transfection using ELISA. 3D6Q44E was expressed with one mutation in either CL only (white), CH1 only (black) or in both CL and CH1 (grey). The interface designs with mutations in both CL and CH1 were named as indicated in the graphs. The expression is given relative to the parental antibody 3D6Q44E.
