Table 2.
Studies included in the systematic review
| Reference | Mothers |
Quantification methods | Type of HMOS quantified | |||
|---|---|---|---|---|---|---|
| Site | Gestation | Secretor status | N | |||
| Asakuma et al. (2007)70 | Japan | Term | Unknown | 20 | HPLC-UV | Acidic |
| Asakuma et al. (2008)42 | Japan | Term | + | 12 | HPLC-UV | Neutral |
| Bao et al. (2007)47 | USA | Term | Unknown | 8 | CE-UV | Acidic |
| Bao et al. (2013)48 | USA | Term | + | 4 | LC-MS | Neutral |
| Chaturvedi et al. (2001)43 | Mexico | Term | + | 11 | HPLC-UV | Neutral |
| Coppa et al. (1999)34 | Italy | Term | + | 18 | HPAEC-PAD | Neutral, acidic |
| Coppa et al. (2011)32 | Italy | Term | +/− | 16/23 | HPAEC-PAD | Neutral |
| Erney et al. (2000)35 | Various world regions | Term | + | 197 | HPAEC-PAD | Neutral |
| Gabrielli et al. (2011)33 | Italy | 27.9 wk | +/− | 42/21 | HPAEC-PAD | Neutral, acidic |
| Goehring et al. (2014)71 | USA | Term | +/− | 13/4 | LC-MS | Neutral, acidic |
| Hong et al. (2014)72 | USA | Term | +/− | 10/10 | LC-MS | Neutral, acidic |
| Kunz et al. (1999)40 | Germany | Term | +/− | 2/2 | HPAEC-PAD | Neutral, acidic |
| Leo et al. (2010)73 | Samoa | Term | Unknown | 16 | HPLC-UV | Neutral, acidic |
| Martin-Sosa et al. (2003)44 | Spain | Term | Unknown | 12 | HPLC-UV | Acidic |
| Nakhla et al. (1999)41 | USA | 29.5 wk | + | 12 | HPAEC-PAD | Acidic |
| Olivares et al. (2015)74 | The Netherlands | Term | +/− | 7/5 | CE-FL | Neutral |
| Smilowitz et al. (2013)45 | USA | Term | +/− | 40/12 | NMR | Neutral |
| Spevacek et al. (2015)75 | USA | Term/preterm | Unknown | 15/13 | NMR | Neutral, acidic |
| Sumiyoshi et al. (2003)39 | Japan | Term | Unknown | 20 | HPLC-UV | Acidic |
| Thurl et al. (2010)31 | Germany | Term | + | 21 | HPAEC-PAD | Neutral, acidic |
| Van Niekerk et al. (2014)46 | South Africa | 500–1250 ga | +/− | 20/21 | HPLC-UV | Neutral, acidic |
Abbreviations: CE-FL, capillary electrophoresis with fluorescence detection; CE-UV, capillary electrophoresis with UV detection; HPAEC-PAD, high-pH anion-exchange chromatography with pulsed amperometric detection; HPLC-UV, high-performance liquid chromatography with UV detection; LC-MS, liquid chromatography with mass spectrometric detection; NMR, nuclear magnetic resonance spectrometry; +, positive; −, negative.
aBirth weight of the premature infants.