Fig. 5. The in vivo imaging of the NP biodistribution in the mice bearing U87 orthotopic tumors. (A) The whole body imaging. (B) The in vivo radiant efficiency of the brain sites. (C) The imaging of the dissected major organs from the mice. (D) The imaging of the brains dissected from the mice. (E) The ex vivo radiant efficiency of the brains. (F) The expression of the nutrient transporters in glioma. (G) The intraglioma penetration of the Cy5-labeled NPs (red). (H) The immunofluorescence colocalization of the Cy5-labeled NPs and SPARC, TfRs, or MRs.