TABLE 4.
Prevalence of Hospitalization for Mental Health Diagnoses in TGNC Children Ages 10–17 Years Relative to Those in Referent Groups
| Categories of Mental Health Disorders | Prevalence in Transfeminine Subjects, N (%) | PR (95% CI)a in Transfeminine Subjects | Prevalence in Transmasculine Subjects, N (%) | PR (95% CI)a in Transmasculine Subjects | ||
|---|---|---|---|---|---|---|
| Versus Reference Males | Versus Reference Females | Versus Reference Males | Versus Reference Females | |||
| All diagnoses of interest | ||||||
| Ever before index date | 58 (13.6) | 9.9 (6.9–14.0) | 8.9 (6.3–12.5) | 99 (15.1) | 10.2 (7.8–13.3) | 7.8 (6.1–10.0) |
| 6 mo before index date | 33 (7.7) | 43.9 (19.7–110.7) | 35.1 (16.7–80.4) | 59 (9.0) | 35.3 (20.4–64.1) | 21.9 (13.7–35.8) |
| Anxiety disorders | ||||||
| Ever before index date | 9 (2.1) | 9.0 (3.2–24.9) | 6.0 (2.3–14.8) | 25 (3.8) | 15.0 (7.7–29.8) | 13.4 (7.1–26.0) |
| 6 mo before index date | 6 (1.4) | 59.8 (7.2–2757.2) | 29.9 (5.3–303.7) | 13 (2.0) | 43.4 (11.9–238.3) | 32.6 (10.0–137.8) |
| Attention deficit disorders | ||||||
| Ever before index date | 20 (4.7) | 9.8 (5.0–19.1) | 14.7 (7.0–31.7) | 14 (2.1) | 4.0 (2.0–7.7) | 9.4 (4.2–20.9) |
| 6 mo before index date | 6 (1.4) | 19.9 (4.2–123.6) | 59.8 (7.2–2755.8) | b | c | 9.9 (1.3–74.0) |
| Autism spectrum disorders | ||||||
| Ever before index date | b | 6.6 (1.4–28.0) | 39.7 (3.9–1957.7) | 5 (0.8) | 5.0 (1.3–16.0) | 8.3 (2.0–32.6) |
| 6 mo before index date | b | c | c | b | 3.3 (0.1–41.0) | c |
| Bipolar disorders | ||||||
| Ever before index date | 12 (2.8) | 30.3 (9.1–129.6) | 13.5 (5.2–36.4) | 18 (2.8) | 10.1 (4.9–20.7) | 9.1 (4.5–18.2) |
| 6 mo before index date | b | 39.7 (3.9–1958.7) | 19.8 (2.8–219.9) | 8 (1.2) | 15.9 (4.6–62.0) | 19.9 (5.3–90.7) |
| Conduct and/or disruptive disorders | ||||||
| Ever before index date | 10 (2.3) | 16.8 (5.5–56.4) | 16.8 (5.5–56.4) | 10 (1.5) | 5.9 (2.4–13.6) | 6.7 (2.7–15.9) |
| 6 mo before index date | 5 (1.2) | 49.7 (5.5–2357.0) | c | b | 39.6 (3.9–1951.1) | 39.6 (3.9–1954.4) |
| Depressive disorders | ||||||
| Ever before index date | 41 (9.6) | 21.1 (12.1–38.1) | 10.3 (6.4–16.4) | 83 (12.7) | 17.8 (12.5–25.2) | 9.1 (6.8–12.1) |
| 6 mo before index date | 26 (6.1) | 68.0 (23.4–269.3) | 54.3 (20.4–182.2) | 49 (7.5) | 104.0 (41.5–335.9) | 21.7 (12.9–37.2) |
| Eating disorders | ||||||
| Ever before index date | b | 6.6 (0.5–57.7) | 2.8 (0.3–14.9) | 6 (0.9) | 29.8 (5.3–302.1) | 4.0 (1.3–10.9) |
| 6 mo before index date | b | c | 3.3 (0.1–41.0) | b | 29.8 (5.3–302.1) | 4.0 (1.3–10.9) |
| Psychoses | ||||||
| Ever before index date | 8 (1.9) | 26.7 (6.4–156.9) | 11.4 (3.6–37.2) | 10 (1.5) | 20.0 (6.2–74.7) | 12.5 (4.4–36.6) |
| 6 mo before index date | 5 (1.2) | 49.7 (5.5–2357.0) | 49.7 (5.5–2355.8) | b | 19.8 (2.8–219.1) | 9.9 (1.8–53.3) |
| Personality disorders | ||||||
| Ever before index date | b | 39.7 (3.9–1958.7) | 19.8 (2.8–219.9) | 8 (1.2) | 26.5 (6.3–155.7) | 8.9 (3.0–26.0) |
| 6 mo before index date | 0 (0) | NC | NC | 7 (1.1) | c | 69.7 (8.9–3144.6) |
| Schizophrenia spectrum disorders | ||||||
| Ever before index date | b | c | 14.8 (1.7–178.2) | b | 9.9 (1.8–53.2) | 13.2 (2.2–90.4) |
| 6 mo before index date | 0 (0) | NC | NC | b | 9.9 (0.1–773.9) | 9.9 (0.1–775.2) |
| Self-inflicted injuries | ||||||
| Ever before index date | b | 6.6 (0.5–57.7) | 4.9 (0.4–34.6) | 13 (2.0) | 65.2 (14.7–596.2) | 13.0 (5.3–33.4) |
| 6 mo before index date | b | c | c | 7 (1.1) | c | 34.8 (6.6–344.4) |
| Substance use disorders | ||||||
| Ever before index date | 8 (1.9) | 5.7 (2.1–14.7) | 4.2 (1.6–10.1) | 16 (2.4) | 6.2 (3.1–12.0) | 6.2 (3.1–12.1) |
| 6 mo before index date | 6 (1.4) | 29.9 (5.3–303.9) | 12.0 (3.0–49.7) | 9 (1.4) | 11.2 (3.8–33.5) | 11.2 (3.8–33.6) |
| Suicidal ideation | ||||||
| Ever before index date | 9 (2.1) | 15.1 (4.8–51.7) | 5.6 (2.2–13.6) | 29 (4.4) | 19.8 (10.2–40.1) | 11.5 (6.5–20.4) |
| 6 mo before index date | 7 (1.6) | c | 23.3 (5.3–140.2) | 17 (2.6) | 24.5 (9.6–70.1) | 21.5 (8.7–57.7) |
NC, not calculated because there were 0 cases among transgender subjects.
a
Logistic regression with exact 95% CIs for rare events (prevalence ≤10% in both the transgender and referent cohorts) or logistic regression with log link and approximate 95% CIs for not-rare events (>10% prevalence in either the transgender or referent cohorts).
b
Fewer than 5 cases were not reported.
c
Not calculated because there were 0 cases among referents.