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Penicillin-cephalosporin cross-reactivity based on side-chain similarity. Penicillin G, benzylpenicillin; penicillin VK, phenoxymethylpenicillin potassium. Approximately 2% of penicillin allergic patients would be expected to react to a cephalosporin, however this number may exceed 30% when administered cephalosporins with identical R1 side chains. Cefditoren and cefpodoxime are oral cephalosporins with the same side chain.
