Table 2.
Adjusted hazard ratio of intracerebral hemorrhage, according to updated cumulative average fasting blood glucose concentration
| <4.00 mmol/L | 4.00–5.59 mmol/L | 5.60–6.09 mmol/L | 6.10–6.99 mmol/L | ≥7.00 mmol/L | |
|---|---|---|---|---|---|
| # of Case / population | 16/687 | 437/65412 | 94/12622 | 72/6331 | 136/11058 |
| Incidence rate, per 1000 person-year | 3.04 | 0.78 | 0.88 | 1.35 | 1.47 |
| Age- and sex-adjusted hazard ratio | 2.95(1.78–4.86) | 1.00 | 1.05(0.84–1.31) | 1.55(1.20–1.99) | 1.69(1.39–2.05) |
| Multivariate-adjusted hazard ratio 1* | 2.81(1.70–4.65) | 1.00 | 1.07(0.85–1.33) | 1.56(1.21–2.00) | 1.68(1.38–2.03) |
| Multivariate-adjusted hazard ratio 2† | 2.04(1.23–3.38) | 1.00 | 0.98(0.78–1.22) | 1.31(1.02–1.69) | 1.59(1.26–2.02) |
| Sensitivity analyses | |||||
| 2-year lag analysis†‡ | 1.70(0.84–3.46) | 1.00 | 1.15(0.88–1.49) | 1.29(0.94–1.78) | 1.96(1.49–2.58) |
| Excluding hypoglycemic-users† | 2.00(1.20–3.31) | 1.00 | 0.97(0.77–1.21) | 1.29(1.00–1.66) | 1.56(1.23–1.98) |
| Excluding antihypertensive-users† | 2.32(1.32–4.07) | 1.00 | 1.16(0.89–1.50) | 1.47(1.09–1.99) | 1.77(1.34–2.33) |
| Excluding aspirin-users† | 1.26(0.76–2.10) | 1.00 | 0.96(0.77–1.21) | 1.21(0.94–1.56) | 1.47(1.16–1.86) |
| Excludingpotential† anticoagulant-users§† | 1.19(0.70–2.00) | 1.00 | 0.93(0.74–1.18) | 1.20(0.93–1.55) | 1.44(1.13–1.83) |
Multivariate-adjusted hazard ratio 1* adjusted for age (year), sex, smoking (current, past, or never), alcohol intake (never, past, light, moderate, or heavy), education (illiteracy/elementary school, middle school, or college/university), physical activity (never, sometimes, or active), average monthly income of each family member (<500, 500–2999, or ≥3000¥), and sodium intake (≥10.0, 6.0–9.9, or <6.0 gram/day).
Multivariate-adjusted hazard ratio 2† included variables in model 1 and further adjusted for updated use of antihypertensive, aspirin, hypoglycemic, and lipid-lowering medications (yes/no for each), and updated cumulative average body mass index (≥30.0, 25.0–29.9, or <25.0 kg/m2), triglycerides(quintile), high-density lipoprotein cholesterol(quintile), low-density lipoprotein cholesterol(quintile), high sensitive C-reactive protein (<1.00, 1.00–2.99, or≥3.00mg/ml), systolic blood pressure(quintile), diastolic blood pressure(quintile), and estimated glomerular filtration rate(quintile).
excluded person time and ICH events from the first 2 years of follow-up
excluded participants with deep venous thrombosis, pulmonary infarction, heart valve disease, or atrial fibrillation or flutter