Skip to main content
. Author manuscript; available in PMC: 2019 Feb 1.
Published in final edited form as: Stem Cells. 2017 Dec 13;36(2):206–217. doi: 10.1002/stem.2739

Figure 5. Working model of human pluripotent stem cell EHT in vitro.

Figure 5

Undifferentiated hESCs/hiPSCs first develop towards mesodermal lineages and generate CD34+ progenitor cells with dual hemato-endothelial potential. CD34+ cells subsequently differentiate into endothelial cells that possess hematopoietic potential (HE) or endothelial cells that lack endothelial potential (non-HE). HE cells can then differentiate further into hematopoietic progenitor cells in a process known as EHT. A subset of non-HE may subsequently transform into other cells of mesenchymal lineages, such as a mesenchymal stromal cell or fibroblast, in a process known as the endothelial-to-mesenchymal transition (EndMT).