Table 2.

Biological pathways that were overrepresented in the gene lists associated with the differentially methylated (A) shores and shelves regions, and (B) enhancer sites.

(A)
Pathway	−log (BH p value)	Gene names
GABA receptor signaling	1.53	ADCY9, MRAS, GABBR1, ADCY10, KCNH2
Gs signaling	1.53	ADCY9, VIPR2, GLP1R, MRAS, ADD1, ADCY10
ERK/MAPK signaling	1.37	YWHAG, ATF1, PPP2R5D, HIST1H3C, MRAS, RAC1, PIK3R5
Breast cancer regulation by stathmin 1	1.37	ADCY9, PPP2R5D, MRAS, RAC1, PIK3R5, ADCY10, TUBB
Superpathway of inositol phosphate compounds	1.37	SOCS3, ATP1A1, PPP2R5D, PIK3R5, MTMR7, INPP5A, SIRPA
IGF-1 signaling	1.37	SOCS3, YWHAG, NOV, MRAS, PIK3R5
CDK5 signaling	1.37	ADCY9, PPP2R5D, NGFR, MRAS, ADCY10
Gap junction signaling	1.36	ADCY9, NOV, MRAS, PIK3R5, ADCY10, TUBB
3-phosphoinositide biosynthesis	1.36	SOCS3, ATP1A1, PPP2R5D, PIK3R5, MTMR7, SIRPA
Renin-angiotensin signaling	1.34	ADCY9, MRAS, RAC1, PIK3R5, ADCY10

(B)
Pathway	−log (BH p value)	Gene names
GABA receptor signaling	2.49	ADCY9, ADCY10, KCNH2
Phospholipase C signaling	2.40	ADCY9, HDAC4, FCGR2A, ADCY10, PLD1
Fc receptor-mediated phagocytosis in macrophages and monocytes	2.09	DOCK1, FCGR2A, PLD1
Gs signaling	1.79	ADCY9, ADORA3, ADCY10
Serotonin receptor signaling	1.79	ADCY9, ADCY10
Cellular effects of sildenafil (Viagra)	1.71	ADCY9, ADCY10, KCNH2
G-protein coupled receptor signaling	1.57	ADCY9, ADORA3, ADCY10, ADRA1B
CXCR4 signaling	1.53	DOCK1, ADCY9, ADCY10
Gap junction signaling	1.50	ADCY9, NOV, ADCY10
GPCR-mediated integration of enteroendocrine signaling exemplified by an L cell	1.41	ADCY9, ADCY10
Endothelin-1 signaling	1.39	ADCY9, ADCY10, PLD1
Leptin signaling in obesity	1.37	ADCY9, ADCY10
Role of NFAT in cardiac hypertrophy	1.35	ADCY9, HDAC4, ADCY10
Dopamine receptor signaling	1.33	ADCY9, ADCY10
ERK/MAPK signaling	1.30	DOCK1, ELF2, YWHAG

The minus log of the Benjamini-Hochberg (BH) corrected p value is given (values >1.3 indicate significance at adjusted P<0.05).