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. Author manuscript; available in PMC: 2018 Aug 1.
Published in final edited form as: Thorac Surg Clin. 2017 Aug;27(3):227–244. doi: 10.1016/j.thorsurg.2017.04.001

Table 10.

A Summary of Studies Supporting the Importance of an R0 Resection for Esophageal Cancer.

Study Design
Year of Study		 Number of
Patients		 Conclusions
Significance of Microscopically Incomplete Resection Margin After Esophagectomy for Esophageal Cancer40 Multicenter retrospective study: propensity score matched 1:3 (2016) 2815 R1 resection margin was an independent predictor of poor prognosis

  • Increased mortality with a hazard ratio of 1.57

  • Increased recurrence with a hazard ratio of 1.56

  • Survival with N0 disease was 66.0 months with R0 resection vs 24.4 months with R1 resection

  • Survival with N1 disease was 23.0 months with R0 resection vs 16.6 months with R1 resection
Positive esophageal proximal resection margin: an important prognostic factor for esophageal cancer that warrants adjuvant therapy41 Single center retrospective study: propensity score matched 1:2 (2016) 111 R1 proximal resection margin conveyed worse prognosis

  • Survival was 68.0 months with R0 resection vs 35.0 months with R1 resection
Margin involvement and outcome in oesophageal carcinoma: a 10-year experience in a specialist unit43 Single center cohort (2004) 212 Negative margins were associated with decreased cancer recurrence and improved survival (RR 2.16) on multivariate analysis
Extent of oesophageal resection for adenocarcinoma of the oesophagogastric junction44 Retrospective cohort (2003) 94 Positive margins impacted survival

  • Survival was 36.3 months with R0 resection vs 11.1 months with R1 resection
Surgical therapy for adenocarcinoma of the cardia: modalities of recurrence and extension of resection45 Retrospective cohort (2001) 116 Survival was correlated with microscopically positive margins

  • Survival was 31.0 months with R0 resection vs 18.0 months with R1 resection
Adenocarcinoma of the esophagogastric junction: Results of surgical therapy based on anatomical/topographic classifications in 1,002 consecutive patients42 Single center cohort (2000) 1002 R0 resection was one of the most important prognostic factors on multivariate analysis

  • 5-year survival was 38.7% with R0 resection vs 13.7% with R1/R2 resection

  • 10-year survival was 28.3% with R0 resection vs 11.6% with R1/R2 resection

Data from Refs 40–45