Table 1.

Summary of published literature relating to the frequency of mismatch repair deficiency and microsatellite instability in oesophageal cancer.

Authors	Year	Oesophageal cancer type	Total n	MMRdef n (%)	MSI-High n (%)	Method
TCGA [24]	2017	SqC	90	NI	0	PCR
		AdC	70		0
		undiff	2		0
Pandilla et al.[57]	2013	SqC	60	NI	6 (10)	PCR
		AdC	30		2 (7)
Farris et al.[38]	2011	SqC	76	5 (7)	5 (7)	IHC, PCR
Vasavi et al.[44]	2010	SqC	45	NI	12 (27)	PCR
		AdC	5		1 (20)
Matsumoto et al.[58]	2007	SqC	62	NI	5 (8)	PCR
Falkenback et al.[48]	2005	AdC	59	2 (3)	2 (3)	IHC, PCR
Naidoo et al.[59]	2005	SqC	100	NI	5 (5)a	PCR
Uehara et al.[23]	2005	SqC	122	49 (40)	6 (5)a	IHC
Evans et al.[47]	2004	AdC	27	6 (22)	0	IHC, PCR
Araki et al.[45]	2004	SqC	100	NI	0	PCR
Hayashi et al.[60]	2003	SqC	30	NI	1 (3)	PCR
Ikeguchi et al.[46]	1999	SqC	20	NI	1 (5)a	PCR
Wu et al.[61]	1998	SqC	92	NI	5 (5)a	PCR
Muzeau et al.[43]	1997	SqC	20	NI	0	PCR
		AdC	26		0
Gleeson et al.[62]	1996	AdC	17	NI	1 (17)	PCR
Keller et al.[63]	1995	AdC	15	NI	2 (13)a	PCR
Ogasawara et al.[64]	1995	SqC	35	NI	21 (60)a	PCR
Meltzer et al.[65]	1994	SqC	42	NI	1 (2)a	PCR
		AdC	36		2 (6)a

Abbreviations: AdC, adenocarcinoma; SqC, squamous cell carcinoma; MMRdef, mismatch repair deficiency; MSI, microsatellite instability; PCR, polymerase chain reaction; IHC, immunohistochemistry; NI, not investigated; undiff, undifferentiated.

^ano distinction made between MSI-High and MSI-Low.