Table 2.

IC₅₀, IC₃₀, and EC₅₀ values calculated from sigmoidal curve fitting of budesonide inhibition in PBMCs

	TNF-α			IL-6			IL-10
	HS	COPD IFE	COPD FE	HS	COPD IFE	COPD FE	HS	COPD IFE	COPD FE
IC50 budesonide (nM)	6.4	4.9	5.6	9.5	10	6.0	N/C	N/C	N/C
IC30 budesonide (nM)	0.2	0.2	0.2	0.6	0.4	0.4	7.6	12	6.3
EC50 budesonide (nM)	1.0	0.9	1.0	1.3	1.0	1.1	1.6	0.8	1.2

Abbreviations: COPD FE, COPD frequent exacerbators; COPD IFE, COPD infrequent exacerbators; HS, healthy smokers; IL, interleukin; N/C, not calculated as inhibition did not reach 50%; PBMC, peripheral blood mononuclear cell; TNF-α, tumor necrosis factor-α.