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. 2018 Apr 19;12:887–899. doi: 10.2147/DDDT.S160314

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© 2018 Xiao et al. This work is published and licensed by Dove Medical Press Limited

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8f and XAN attenuate the LPS-induced ALI in mice. Mice were administrated with 8f and XAN for three consecutive days before given intratracheal instillation of LPS, 6 h later mice were anesthetized and killed. Bronchoalveolar lavage fluid and lung tissues were collected for further tests. (A) Total amount of cells in BALF. (B) Protein concentration in BALF. (C) W/D ratio. (D) The number of neutrophils in BALF. (E) Serum level of the cytokine TNF-α. (F) Serum level of the cytokine IL-6. (G) BALF level of the cytokine TNF-α. (H) BALF level of the cytokine IL-6. Statistical significance relative to the LPS group was indicated, n≥5, ^*P<0.05, ^**P<0.01.

Abbreviations: XAN, xanthohumol; LPS, lipopolysaccharide; ALI, acute lung injury; BALF, bronchoalveolar lavage fluid; W/D, wet/dry; TNF-α, tumor necrosis factor-α; CON, control group.