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. 2018 Apr 19;12:887–899. doi: 10.2147/DDDT.S160314

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© 2018 Xiao et al. This work is published and licensed by Dove Medical Press Limited

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The 8f and XAN inhibited macrophages in filtration through F4/80-staining, LY-6G-staining, ameliorated histopathological changes, and inflammatory gene expression in lung tissue of LPS-stimulated ALI mice. (A) F4/80 immunohistochemical staining. (B) H&E staining. (C) LY-6G immunohistochemical staining. (D) The mRNA levels of the inflammatory mediators TNF-α, IL-6, IL-1β, and VCAM-1. Statistical significance relative to the LPS group was indicated, n≥5, ^**P<0.01.

Abbreviations: XAN, xanthohumol; IL-6, interleukin-6; LPS, lipopolysaccharide; ALI, acute lung injury; H&E, hematoxylin and eosin; VCAM-1, vascular cell adhesion molecule 1; TNF-α, tumor necrosis factor-α; CON, control group.