Table 2.

Specific variables* collected at baseline and follow-up in the Health and Prevention Enhancement (H-PEACE) study

Specific items	List
SNP	SNP variation by genome-wide SNP arrays (Affymetrix platform of Axiom Customized Genome-Wide Human Assay)†
Heart	Coronary calcium score CT Echocardiography, treadmill test	Coronary CT angiography Holter monitoring
Stroke	Lp (a) lipoprotein (a), homocysteine Echocardiography, carotid Doppler	Brain MRI Brain and carotid MRA
Kidney	24-hour urinary uric acid, creatinine, urea nitrogen, protein and microalbumin 24-hour urinary electrolytes including sodium, potassium, calcium, phosphorus and magnesium 24-hour urinary citrate and oxalate	Serum cystatin C Dynamic kidney CT
Intestine	Abdominal sonography Colonoscopy with pathological reports	Abdomino-pelvic CT
Obesity	24-hour recall diet questionnaire Serum insulin levels	Abdomen and thigh CT (for visceral fat) Whole-body DEXA
Dementia	Apo-E genotyping MR double time	Brain MRI, brain MRA, hippocampus (non-contrast)
Prostate	Free PSA Uroflowmetry Ultrasonography (for residual urine)	Transrectal sonography Prostate MRI (non-contrast)
Sex hormones	Testosterone (men≥60 years) Total and free E2, LH, FSH (postmenopausal women after 5 years from menopause)
Cigarette smoking	CO levels in exhalation, urine cotinine levels Laryngoscopy, low-dose screening chest CT
Bone	Bone densitometry (men≥50 years and postmenopausal women) Site-specific X-ray digital imaging (AP and Lat.) Site-specific bone CT
Dental	Dental, peridental and periodontal examination
Nutrition	Plasma vitamin B6 profile (pyridoxal phosphate, pyridoxic acid) Plasma vitamin A and E (HPLC)	Plasma 25(OH)D Vitamin C, B12 and folate levels Serum selenium, zinc, copper levels
Allergy	Multiple allergen simultaneous test IgE (PRIST) Skin prick test (inhalant)	Methacholine bronchial challenge test Histograms of categorised shapes ear detection X-ray of paranasal sinus
Hepatitis	HBV viral load, HBeAg (quantitation), HBeAb HCV PCR	Liver fibrosis scan
Heavy mineral	Cd, Pb, Hg, As, Al, Se, Cu, Zn, Cr, Co, Mn, Mo
Other	HPV genotyping CLO test or UBT test for current Helicobacter pylori infection

*The specific variables were selected for the health screenees according to the specific test or physician’s request.

†GWAS genotyping was performed among the 17 455 cohort participants who provided informed consent and donated blood samples. We categorised the 17 455 participants with blood specimens as the Gene-environmental interaction and phenotype study (a specific subcohort derived from the H-PEACE study). SNP testing was performed for research purposes and was not a routinely performed test.

CLO, Campylobacter-like organism; DEXA, dual-energy X-ray absorptiometry; GWAS, genome-wide association study; FSH, follicle-stimulating hormone; HPLC, high-performance liquid chromatography; HPV, human papillomavirus; LH, luteinising hormone; MRA, magnetic resonance angiogram; PRIST, paper radioimmunosorbent test, PCR, polymerase chain reaction; PSA, prostate-specific antigen; SNP, single-nucleotide polymorphism; UBT, urea breath test.