. 2018 Apr 19;8(4):e019327. doi: 10.1136/bmjopen-2017-019327

Table 5.

Morbidity rates after active follow-up with specific measurements in the Health and Prevention Enhancement study

Test	Definition	Participants tested N	Follow-up years Median (IQR)	Clinical finding* N
Coronary calcification	Coronary artery calcium score>400 at coronary CT	12 846	5.6 (3.2–8.0)	805
Atrial fibrillation	ECG and/or ambulatory ECG	91 076	4.1 (2.1–6.5)	446
Left bundle branch block	ECG and/or ambulatory ECG	91 076	4.1 (2.1–6.5)	64
Chronic kidney disease	Estimated GFR†<60 mL/min/1.73 m²	91 197	4.0 (2.1–6.5)	5372
Visceral obesity	Men>10 000 cm², Women>8000 cm² in abdomen visceral fat CT	34 771	5.0 (3.0–7.4)	23 126
Fatty liver	Abdominal sonography and/or abdominal CT	34 771	5.0 (3.0–7.4)	Mild	10 244
				Moderate	5963
				Severe	688
Abnormal thyroid function	Thyroid hormone measurement	77 313	4.1 (2.2–6.6)	Hypothyroidism	363
Abnormal thyroid function	Thyroid hormone measurement	77 313	4.1 (2.2–6.6)	Hyperthyroidism	1260
Helicobacter pylori infection	H. pylori IgG Ab and/or CLO test or UBT test for current H. pylori infection	81 142	4.2 (2.3–6.7)	44 304
High-risk HPV infection	HPV 16, 18 positive finding in HPV genotyping	12 999	5.0 (3.1–7.2)	1462
Parasite infection	Stool examination	82 493	4.1 (2.2–6.6)	Clonorchis sinensis	1262
				Ascaris lumbricoides	124
				Trichuris trichiura	256
				Metagonimus yokogawai	412
Premalignant conditions of stomach	Gastroendoscopy with pathological reports	66 451	4.2 (2.3–6.7)	Atrophic gastritis	23 896
Premalignant conditions of stomach	Gastroendoscopy with pathological reports	66 451	4.2 (2.3–6.7)	Intestinal metaplasia	10 187
Malignant gastric cancer	Gastroendoscopy with pathological reports	66 451	4.2 (2.3–6.7)	299
SIL	Pap smear and pathological report	12 951	5.0 (3.1–7.2)	Total SIL	375
				Low grade	315
				High grade	60
Premalignant colonic neoplasms	Colonoscopy with pathological reports	46 746	4.8 (2.9–7.1)	Adenoma	18 656‡
				Serrated polyp	1178‡
				Carcinoid	150
Malignant colon cancer	Colonoscopy with pathological reports	46 746	4.8 (2.9–7.1)	262
Low bone density	Bone densitometry	35 695	4.8 (2.9–7.2)	Osteopenia Male Female	2322 8279
Low bone density	Bone densitometry	35 695	4.8 (2.9–7.2)	Osteoporosis Male Female	305 1348
Periodontitis	Dental examination	43 232	4.9 (2.8–7.2)	Total periodontitis	15 204
				Mild to moderate	14 292
				Severe	912

*The number of findings among the participants who were at risk.

†The GFR was estimated by the Chronic Kidney Disease Epidemiology Collaboration equation and the Modification of Diet in Renal Disease formula.

‡Adenoma and serrated polyp detection rate were calculated in participants aged 50–75 years.

CLO, Campylobacter-like organism; GFR, glomerular filtration rate; HPV, human papillomavirus; SIL, squamous intraepithelial lesion; UBT, urea breath test.