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. 2018 Apr 19;11:2227–2239. doi: 10.2147/OTT.S160895

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© 2018 Gao et al. This work is published and licensed by Dove Medical Press Limited

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Combination treatment of IFN-α1b and 5-FU induced cell apoptosis through upregulating miR-26a mediated by p53.

Notes: After the combination treatment of IFN-α1b and 5-FU, the number of apoptotic cells (A), the proportion of cells with the loss of ΔΨm (B), and mitochondrial cytochrome c release (C) of HCC cells were obviously increased in comparison with the control. Obviously smaller tumor volumes (D) and more apoptotic tumor cells (E) were found in the HCC tissues of nude mice models treated with IFN-α1b +5-FU compared with the control. (F–H) This combination treatment induced significant increases in p53 and miR-26a levels and an obvious decrease in Mcl1 levels in HCC cells and tissues. *P<0.05 and **P<0.01.

Abbreviations: 5-FU, 5-fluorouracil; HCC, hepatocellular carcinoma; IFN-α1b, interferon-α1b; miR-26a, microRNA-26a; TUNEL, transferase-mediated dUTP nick end-labeling.