Table 1.
Demographic and laboratory data of all patients and controls.
| Variables | Controls (n = 40) | CHC (n = 42) | LC (n = 45) | HCC (n = 38) |
|---|---|---|---|---|
| Age | 47.0 ± 3.5 | 46.4 ± 7.3 | 51.3 ± 4.7 | 48.1 ± 4.1 |
| Gender (M:F) | 3:1 | 3:2 | 7:5 | 6:4 |
| Liver Function Tests (mean ± SD) | ||||
| AST (U/L) | 21.32 ± 1.07 | 46.14 ± 4.77 a | 50.84 ± 5.00 a | 76.40 ± 7.34 b |
| ALT (U/L) | 23.16 ± 1.95 | 44.12 ± 5.50 a | 50.84 ± 5.00 a | 76.40 ± 7.34 b |
| ALP (U/L) | 189 ± 41 | 331 ± 36 a | 336 ± 48 a | 420 ± 33 b |
| Albumin (g/dL) | 4.4 ± 0.5 | 3.60 ± 0.74 | 3.8 ± 0.72 | 3.08 ± 0.48 |
| Prothrombin Concentration | 95.6 ± 3.4 | 89.6 ± 4.8 | 41.5 ± 11.1 b | 69.4 ± 3.7 a |
| AFP (IU/mL) | 3.12 ± 0.08 | 8.86 ± 0.11 a | 10.11 ± 0.11 a | 55.18 ± 0.44 b |
| DCP (mAU/ ml) | 30.42 ± 0.70 | 121.49 ± 0.59 a | 123.62 ± 0.38 a | 456.52 ± 0.66 b |
Data are expressed as mean ± standard deviations (SD).
Chronic hepatitis C (CHC); liver cirrhosis (LC); hepatocellular carcinoma (HCC).
Normal range for alanine aminotransferase (ALT) and aspartate aminotransferase (AST) is up to 40 IU/L.
Normal range for alkaline phosphatase (ALP) is up to 250 U/L.
Normal range for albumin is 3.5–5 g/dl.
Normal range for prothrombin concentration is 80–1 00%.
Normal range for alpha-fetoprotein (AFP) is 0.1–9.6 IU/mL.
mAU/ml = milli-absorbance unit/ml.
Normal range for des-γ-carboxy prothrombin (DCP) ≤40 mAU/ml.
a
p < 0.001 significant increase than control group.
b
p < 0.001 significant increase than CHC and LC groups.