Table 3. Logistic regression analysis of the association between the IL1 SNPs and breast cancer risk.
| SNP ID | Model | Genotype | control | case | OR (95% CI) | P-value | AIC | BIC |
|---|---|---|---|---|---|---|---|---|
| rs10490571 | Codominant | C/C | 432 (68.8%) | 328 (61.9%) | 1 | |||
| C/T | 182 (29%) | 172 (32.5%) | 1.25 (0.87–1.79) | 0.047 | 800.2 | 817.7 | ||
| T/T | 14 (2.2%) | 30 (5.7%) | 2.82 (1.12–7.08) | |||||
| Dominant | C/C | 432 (68.8%) | 328 (61.9%) | 1 | ||||
| C/T-T/T | 196 (31.2%) | 202 (38.1%) | 1.36 (0.96–1.92) | 0.079 | 801.3 | 814.3 | ||
| Recessive | C/C-C/T | 614 (97.8%) | 500 (94.3%) | 1 | ||||
| T/T | 14 (2.2%) | 30 (5.7%) | 2.63 (1.05–6.55) | 0.031 | 799.7 | 812.8 | ||
| Log-additive | — | — | — | 1.40 (1.04–1.87) | 0.026 | 799.4 | 812.5 | |
| rs1143627 | Codominant | G/G | 144 (22.9%) | 136 (25.7%) | 1 | |||
| A/G | 342 (54.5%) | 238 (44.9%) | 0.74 (0.49–1.11) | 0.054 | 800.5 | 818 | ||
| A/A | 142 (22.6%) | 156 (29.4%) | 1.18 (0.74–1.87) | |||||
| Dominant | G/G | 144 (22.9%) | 136 (25.7%) | 1 | ||||
| A/G-A/A | 484 (77.1%) | 394 (74.3%) | 0.86 (0.59–1.27) | 0.45 | 803.8 | 816.9 | ||
| Recessive | G/G-A/G | 486 (77.4%) | 374 (70.6%) | 1 | ||||
| A/A | 142 (22.6%) | 156 (29.4%) | 1.44 (0.99–2.10) | 0.056 | 800.7 | 813.8 | ||
| Log-additive | — | — | — | 1.09 (0.86–1.38) | 0.47 | 803.8 | 816.9 | |
| rs16944 | Codominant | G/G | 142 (22.6%) | 160 (30.2%) | 1 | |||
| A/G | 344 (54.8%) | 236 (44.5%) | 0.60 (0.41–0.90) | 0.034 | 799.6 | 817 | ||
| A/A | 142 (22.6%) | 134 (25.3%) | 0.83 (0.52–1.32) | |||||
| Dominant | G/G | 142 (22.6%) | 160 (30.2%) | 1 | ||||
| A/G-A/A | 243 (77.4%) | 370 (69.8%) | 0.67 (0.46–0.97) | 0.035 | 799.9 | 813 | ||
| Recessive | G/G-A/G | 243 (77.4%) | 396 (74.7%) | 1 | ||||
| A/A | 142 (22.6%) | 134 (25.3%) | 1.15 (0.79–1.69) | 0.46 | 803.8 | 816.9 | ||
| Log-additive | — | — | — | 0.90 (0.71–1.14) | 0.39 | 803.6 | 816.7 | |
| rs1143623 | Codominant | C/C | 198 (31.6%) | 202 (38.3%) | 1 | |||
| C/G | 332 (53%) | 220 (41.7%) | 0.65 (0.45–0.94) | 0.023 | 796.1 | 813.5 | ||
| G/G | 96 (15.3%) | 106 (20.1%) | 1.08 (0.67–1.74) | |||||
| Dominant | C/C | 198 (31.6%) | 202 (38.3%) | 1 | ||||
| C/G-G/G | 428 (68.4%) | 326 (61.7%) | 0.74 (0.53–1.05) | 0.093 | 798.8 | 811.9 | ||
| Recessive | C/C-C/G | 530 (84.7%) | 422 (79.9%) | 1 | ||||
| G/G | 96 (15.3%) | 106 (20.1%) | 1.38 (0.90–2.13) | 0.14 | 799.4 | 812.5 | ||
| Log-additive | — | — | — | 0.96 (0.76–1.21) | 0.73 | 801.5 | 814.6 |
Abbreviations: OR: odds ratio, CI: confidence interval AIC: Akaike's Information criterion; BIC: Bayesian Information criterion.
*p value < 0.05 indicates statistical significance.