Table 4. Logistic regression analysis of the association between the IL1 SNPs and breast cancer risk by stratification analysis.
| SNP ID | Premenopausal | Postmenopausal | ER+ | ER- | PR+ | PR- | HER2+ | HER2- | ||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| OR | 95%CI | P | OR | 95%CI | P | OR | 95%CI | P | OR | 95%CI | P | OR | 95%CI | P | OR | 95%CI | P | OR | 95%CI | P | OR | 95%CI | P | |
| rs11674595 | 1.29 | 0.90–1.85 | 0.158 | 1.07 | 0.78–1.49 | 0.670 | 1.17 | 0.85–1.62 | 0.334 | 1.14 | 0.8–1.65 | 0.465 | 1.15 | 0.82–1.63 | 0.422 | 1.17 | 0.84–1.63 | 0.361 | 1.19 | 0.87–1.64 | 0.275 | 1.11 | 0.77–1.61 | 0.577 |
| rs4851527 | 0.76 | 0.54–1.08 | 0.122 | 0.99 | 0.74–1.33 | 0.961 | 0.92 | 0.69–1.24 | 0.601 | 0.85 | 0.61–1.19 | 0.353 | 0.93 | 0.68–1.28 | 0.676 | 0.86 | 0.63–1.17 | 0.332 | 0.89 | 0.66–1.19 | 0.430 | 0.90 | 0.64–1.27 | 0.554 |
| rs719250 | 0.95 | 0.67–1.34 | 0.767 | 0.85 | 0.62–1.15 | 0.284 | 0.74 | 0.54–1.01 | 0.056 | 1.13 | 0.81–1.57 | 0.483 | 0.80 | 0.57–1.11 | 0.180 | 0.98 | 0.71–1.33 | 0.873 | 0.94 | 0.7–1.27 | 0.706 | 0.80 | 0.56–1.15 | 0.232 |
| rs3218896 | 1.11 | 0.71–1.72 | 0.651 | 0.93 | 0.62–1.39 | 0.721 | 0.84 | 0.55–1.27 | 0.399 | 1.25 | 0.82–1.9 | 0.310 | 0.86 | 0.55–1.34 | 0.506 | 1.13 | 0.76–1.69 | 0.541 | 1.12 | 0.76–1.64 | 0.577 | 0.83 | 0.51–1.35 | 0.450 |
| rs3218977 | 0.85 | 0.58–1.23 | 0.384 | 0.97 | 0.7–1.33 | 0.829 | 1.07 | 0.78–1.47 | 0.669 | 0.72 | 0.49–1.06 | 0.090 | 1.04 | 0.74–1.47 | 0.804 | 0.81 | 0.57–1.14 | 0.223 | 0.84 | 0.61–1.16 | 0.286 | 1.04 | 0.73–1.5 | 0.817 |
| rs2072472 | 1.26 | 0.88–1.81 | 0.210 | 1.14 | 0.82–1.57 | 0.437 | 1.14 | 0.82–1.57 | 0.442 | 1.26 | 0.88–1.8 | 0.208 | 1.15 | 0.81–1.63 | 0.424 | 1.22 | 0.87–1.7 | 0.246 | 1.28 | 0.94–1.75 | 0.123 | 1.05 | 0.72–1.53 | 0.813 |
| rs10490571 | 1.31 | 0.89–1.94 | 0.173 | 1.46 | 1.04–2.04 | 0.029 | 1.48 | 1.06–2.07 | 0.023 | 1.28 | 0.87–1.89 | 0.212 | 1.73 | 1.22–2.46 | 0.002 | 1.12 | 0.77–1.62 | 0.550 | 1.59 | 1.15–2.22 | 0.006 | 1.11 | 0.74–1.68 | 0.607 |
| rs12712127 | 1.24 | 0.87–1.78 | 0.228 | 1.39 | 1.02–1.89 | 0.038 | 1.34 | 0.98–1.84 | 0.062 | 1.30 | 0.92–1.85 | 0.140 | 1.57 | 1.14–2.18 | 0.006 | 1.12 | 0.81–1.57 | 0.490 | 1.52 | 1.12–2.06 | 0.007 | 1.05 | 0.73–1.53 | 0.780 |
| rs956730 | 0.86 | 0.59–1.25 | 0.437 | 1.02 | 0.74–1.4 | 0.914 | 0.90 | 0.65–1.24 | 0.506 | 1.04 | 0.73–1.48 | 0.844 | 0.87 | 0.61–1.24 | 0.435 | 1.03 | 0.74–1.43 | 0.852 | 0.89 | 0.64–1.22 | 0.458 | 1.06 | 0.74–1.53 | 0.745 |
| rs3917225 | 1.02 | 0.74–1.41 | 0.880 | 1.26 | 0.96–1.67 | 0.097 | 1.13 | 0.86–1.5 | 0.390 | 1.21 | 0.88–1.65 | 0.242 | 1.15 | 0.85–1.55 | 0.372 | 1.18 | 0.88–1.57 | 0.273 | 1.24 | 0.94–1.64 | 0.122 | 1.05 | 0.76–1.45 | 0.788 |
| rs3917318 | 0.75 | 0.55–1.02 | 0.066 | 0.83 | 0.63–1.09 | 0.181 | 0.77 | 0.58–1.01 | 0.057 | 0.84 | 0.62–1.14 | 0.263 | 0.74 | 0.55–1 | 0.048 | 0.85 | 0.64–1.12 | 0.249 | 0.72 | 0.55–0.94 | 0.016 | 0.93 | 0.68–1.28 | 0.659 |
| rs3783550 | 0.98 | 0.71–1.36 | 0.906 | 1.13 | 0.85–1.49 | 0.412 | 1.06 | 0.79–1.41 | 0.706 | 1.08 | 0.78–1.48 | 0.654 | 1.14 | 0.84–1.55 | 0.389 | 1.00 | 0.74–1.34 | 0.985 | 1.04 | 0.78–1.38 | 0.792 | 1.11 | 0.8–1.53 | 0.546 |
| rs3783546 | 0.98 | 0.71–1.36 | 0.906 | 1.13 | 0.85–1.49 | 0.412 | 1.06 | 0.79–1.41 | 0.706 | 1.08 | 0.78–1.48 | 0.654 | 1.14 | 0.84–1.55 | 0.389 | 1.00 | 0.74–1.34 | 0.985 | 1.05 | 0.79–1.4 | 0.720 | 1.08 | 0.78–1.5 | 0.632 |
| rs2856838 | 1.17 | 0.82–1.67 | 0.377 | 1.29 | 0.95–1.76 | 0.099 | 1.26 | 0.92–1.71 | 0.148 | 1.23 | 0.87–1.74 | 0.251 | 1.39 | 1–1.92 | 0.050 | 1.12 | 0.81–1.56 | 0.489 | 1.25 | 0.92–1.7 | 0.153 | 1.24 | 0.87–1.76 | 0.245 |
| rs1609682 | 0.97 | 0.7–1.35 | 0.875 | 1.14 | 0.86–1.51 | 0.374 | 1.07 | 0.8–1.42 | 0.655 | 1.07 | 0.78–1.48 | 0.680 | 1.16 | 0.85–1.57 | 0.346 | 0.99 | 0.74–1.34 | 0.959 | 1.06 | 0.8–1.41 | 0.692 | 1.08 | 0.78–1.5 | 0.632 |
| rs3783521 | 0.98 | 0.71–1.36 | 0.906 | 1.13 | 0.85–1.49 | 0.412 | 1.06 | 0.79–1.41 | 0.706 | 1.08 | 0.78–1.48 | 0.654 | 1.14 | 0.84–1.55 | 0.389 | 1.00 | 0.74–1.34 | 0.985 | 1.05 | 0.79–1.4 | 0.720 | 1.08 | 0.78–1.5 | 0.632 |
| rs2853550 | 0.95 | 0.55–1.63 | 0.847 | 1.04 | 0.65–1.65 | 0.874 | 0.90 | 0.56–1.46 | 0.669 | 1.15 | 0.69–1.91 | 0.597 | 0.85 | 0.5–1.44 | 0.540 | 1.14 | 0.72–1.83 | 0.573 | 0.90 | 0.56–1.45 | 0.664 | 1.16 | 0.69–1.95 | 0.569 |
| rs1143643 | 1.02 | 0.75–1.39 | 0.898 | 0.84 | 0.64–1.1 | 0.213 | 0.86 | 0.66–1.13 | 0.282 | 0.98 | 0.72–1.34 | 0.922 | 0.85 | 0.63–1.14 | 0.268 | 0.97 | 0.73–1.29 | 0.840 | 0.89 | 0.68–1.17 | 0.394 | 0.94 | 0.69–1.29 | 0.717 |
| rs3136558 | 0.91 | 0.66–1.26 | 0.577 | 0.95 | 0.72–1.26 | 0.741 | 1.00 | 0.76–1.32 | 0.993 | 0.85 | 0.62–1.17 | 0.327 | 1.00 | 0.74–1.35 | 0.993 | 0.88 | 0.66–1.18 | 0.399 | 0.95 | 0.72–1.26 | 0.733 | 0.91 | 0.66–1.26 | 0.582 |
| rs1143630 | 0.92 | 0.61–1.39 | 0.697 | 0.91 | 0.64–1.31 | 0.627 | 0.76 | 0.52–1.11 | 0.159 | 1.15 | 0.78–1.7 | 0.476 | 0.72 | 0.47–1.09 | 0.117 | 1.11 | 0.77–1.59 | 0.568 | 0.89 | 0.62–1.27 | 0.515 | 0.96 | 0.64–1.46 | 0.863 |
| rs1143627 | 1.04 | 0.77–1.42 | 0.783 | 1.11 | 0.85–1.46 | 0.433 | 1.38 | 1.05–1.81 | 0.023 | 0.78 | 0.57–1.06 | 0.113 | 1.41 | 1.05–1.89 | 0.023 | 0.86 | 0.65–1.14 | 0.292 | 1.14 | 0.87–1.49 | 0.341 | 1.01 | 0.74–1.38 | 0.968 |
| rs16944 | 0.93 | 0.68–1.27 | 0.639 | 0.89 | 0.68–1.17 | 0.407 | 0.73 | 0.56–0.96 | 0.026 | 1.22 | 0.9–1.66 | 0.202 | 0.71 | 0.53–0.96 | 0.025 | 1.12 | 0.85–1.49 | 0.424 | 0.85 | 0.65–1.11 | 0.239 | 1.00 | 0.73–1.37 | 1.000 |
| rs1143623 | 0.95 | 0.69–1.31 | 0.759 | 0.97 | 0.741.28 | 0.821 | 0.80 | 0.6–1.06 | 0.112 | 1.24 | 0.91–1.7 | 0.166 | 0.86 | 0.63–1.15 | 0.305 | 1.07 | 0.8–1.42 | 0.649 | 0.91 | 0.7–1.2 | 0.522 | 1.04 | 0.76–1.43 | 0.813 |
SNP: single nucleotide polymorphism, OR: odds ratio, CI: confidence interval, HWE: Hardy–Weinberg equilibrium , p ≤ 0.05 indicates statistical significance.