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. 2018 Apr 6;9(26):18041–18052. doi: 10.18632/oncotarget.24710

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Copyright: © 2018 Salzwedel et al.

This is an open-access article distributed under the terms of the Creative Commons Attribution License 3.0 (CC BY 3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

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Cytotoxicity of OAd-hamIFN (100 VP/cell) and chemo-monotherapies was compared to the cytocidal effect of OAd-hamIFN combination therapies with respective doses of 5-FU, GEM, and CDDP. Each column represents the mean of three experimental replicates, with the capped bars on the top of columns representing the standard deviation. Within each of the nine conditions, a two-way ANOVA was performed with dose and virus effects. All effects had p < 0.025, indicating that the killing effect of OAd-hamIFN+ Chemotherapy was superior to the killing effect of a drug or OAd-hamIFN alone.