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. 2018 Apr 6;9(26):18069–18083. doi: 10.18632/oncotarget.24725

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Copyright: © 2018 Takahashi et al.

This is an open-access article distributed under the terms of the Creative Commons Attribution License 3.0 (CC BY 3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

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(A) In a comprehensive analysis of the expressions of TJ-genes as a discovery phase, frozen-stocked specimens from post-eradication mucosa (1. AA, 2. ANA) and H. pylori-infected mucosa (3. AA, 4. ANA) were studied using a human tight junction genes RT² PCR array analysis (N = 3–5). (B) In the validation phase, the expression of ZO-1 mRNA in ANA was significantly diminished compared to that in AA (N = 18, ^*P = 0.008, Student`s t-test). (C, D) A representative image of an immunohistochemical study for ZO-1 and snail (×400). The expression of ZO-1 in ANA (C: right) was decreased in comparison to that in AA (C: left), although that of snail in ANA (D: right) was increased in comparison to that in AA (D: left).

(A) In a comprehensive analysis of the expressions of TJ-genes as a discovery phase, frozen-stocked specimens from post-eradication mucosa (1. AA, 2. ANA) and H. pylori-infected mucosa (3. AA, 4. ANA) were studied using a human tight junction genes RT² PCR array analysis (N = 3–5). (B) In the validation phase, the expression of ZO-1 mRNA in ANA was significantly diminished compared to that in AA (N = 18, ^*P = 0.008, Student`s t-test). (C, D) A representative image of an immunohistochemical study for ZO-1 and snail (×400). The expression of ZO-1 in ANA (C: right) was decreased in comparison to that in AA (C: left), although that of snail in ANA (D: right) was increased in comparison to that in AA (D: left).