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. 2018 Apr 6;9(26):18069–18083. doi: 10.18632/oncotarget.24725

Figure 5. Role of let-7a in barrier dysfunction by ABC stimulation.

Figure 5

We performed an in vitro study using AGS to clarify the role of let-7a in maintaining the barrier function. (A) Compared to control, the let-7a expression was significantly inhibited in the group stimulated with weak acid or bile acid, and even further inhibited in the ABC-stimulated group (N = 6, P < 0.05, Tukey-Kramer test). (B) The plasmid of let-7a inhibitor, mimic, and the negative control were transfected in AGS to investigate the effect on the induction of HMGA2 as well as snail (N = 5). (C) Transfection with the let-7a inhibitor plasmid increased the expressions of HMGA2 and snail at the mRNA levels. Transfection with the let-7a mimic plasmid decreased their expressions (N = 5).