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. 2018 Apr 6;9(26):18099–18114. doi: 10.18632/oncotarget.24266

Figure 4. Differential radiosensitization upon esiRNA mediated knockdown of tumor-driving genes mutated in FaDu and SAS non-responder cell lines.

Figure 4

Clonogenic radiation survival (6 Gy) of the non-responder cell lines FaDu and SAS upon esiRNA-mediated knockdown of 24 indicated genes identified by whole exome sequencing. In addition to knockdown, cells were treated with AIIB2 and Cetuximab alone or in combination (RLUC esiRNA and IgG were used as control). Surviving fraction (grey bars) and sensitizing enhancement ratio (red dots) upon indicated treatments are presented. Results show mean ± SEM, n = 3, two-sided t-test, *P < 0.05; **P < 0.01; ***P < 0.001.