Table 3. Sensitivity of B-ALL cell lines to drugs.
| Drugs | VR-ALL (a) | RS4 ;11 (b) | SUP-B15 (c) | P-values | |
|---|---|---|---|---|---|
| Bortezomid | a vs b | P = 0.01 | |||
| 3.11 × 10−9 | 1.5 × 10−9 | 4.1 × 10−9 | a vs c | P = 0.5 | |
| Cytarabine | a vs b | P = 0.11 | |||
| 5.3 × 10−7 | 8.4 × 10−7 | 6.4 × 10−7 | a vs c | P = 0.15 | |
| Dexamethasone | a vs b | P = 0.03 | |||
| 1.2 × 10−8 | 3.1 × 10-9 | 4.2 × 10−9 | a vs c | P = 0.04 | |
| Doxorubicin | a vs b | P = 0.11 | |||
| 1.6 × 10−8 | 1.9 × 10-8 | 2.1 × 10−8 | a vs c | P = 0.03 | |
| MG132 | a vs b | P = 0.01 | |||
| 1.8 × 10−7 | 1.2 × 10−7 | 1.7 × 10−7 | a vs c | P = 0.17 |
Cells were cultured for 48 h with increasing concentration of each drug. Then cell viability was assessed through MTS assay. The effective concentration to induce 50% reduction of B-ALL cells viability (IC50) derived from the equations that best fit the linear range of the dose-response curve. Each experimental condition was done in 8 replicates and repeated at least two times. “vs”: versus.