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. 2018 Apr 6;9(26):18480–18493. doi: 10.18632/oncotarget.24883

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Copyright: © 2018 Nakayama et al.

This is an open-access article distributed under the terms of the Creative Commons Attribution License 3.0 (CC BY 3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

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(A) Selectivity of TP-064N at 10 μM (■) and 1 μM (■) and of TP-064 at 10 μM (■) and 1 μM (■) for PRMT1, 3, 4, 5, 6, 7, 8, and 9 as well as for 24 histone and DNA methyltransferases was assessed. Dose response data are presented in the top panel as IC₅₀s (μM). (B) Mechanism of action of TP-064 was assessed by determining IC₅₀ of both substrates values at various concentrations.