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. 2018 Apr 6;9(26):18494–18509. doi: 10.18632/oncotarget.24892

Figure 4. Effects of FG-3019 combined with PEM on the growth of orthotopic xenografts of a mesothelioma cell line, ACC-MESO-4.

Figure 4

(A) Macroscopic findings. The tumors (arrows) grew in the pleural space (upper figure). The tumor including thoracic organs was dissected (lower figure). (B) Weight of tumors. Average tumor weights of FG-3019-treated group were significantly lower than IgG control group. (C, D) Quantitation of proliferation using Ki-67 antibody. (E, F) Quantitation of apoptosis using TUNEL assay (arrows). Color contrast was equally increased in (E) and (F). N = 6 (IgG), N = 6 (FG-3019), N = 6 (IgG + PEM), N = 6 (FG-3019 + PEM) in (B)–(F); means ± SEM, *P < 0.05, **P < 0.01, ***P < 0.005. N is the number of mice used. Pathological specimens were generated for each mouse and analyzed. Bar; 5 mm in (A), 20 μm in (C)-(F). N.S., not significant.