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. 2018 Apr 6;9(26):18494–18509. doi: 10.18632/oncotarget.24892

Figure 6. Mechanism of apoptosis induction by FG-3019 in mouse xenograft model.

Figure 6

(A) Western blot analysis of total lysates from grown mesothelioma tissue. (B) Corresponding densitometry of XIAP. Protein levels of XIAP were significantly decreased in FG-3019-treated group. There was a synergistic effect on the XIAP expression by the combination of FG-3019 + PEM. N = 3-4 for each group in (A), (B); means ± SEM, *P < 0.05, **P < 0.01, ***P < 0.005. Each protein level was normalized to β-actin. XIAP, X-linked inhibitor of apoptosis. N.S., not significant.