Table 2. Sensitivity, specificity, and accuracy for CLv2 and OLcfDNA panel determined with reference standard DNA extracted from synthetic plasma samples.
| Results including all reference dilutions (5% AF, 1% AF, 0.1% AF and wildtype) | |||
|---|---|---|---|
| CLv2 | OLcfDNA | ||
| All 8 hotspot mutations | Sensitivity | 81.3% | 95.8% |
| Specificity | 93.8% | 100% | |
| PPV | 97.5% | 100% | |
| NPV | 62.5% | 88.9% | |
| Accuracy | 84.4% | 96.9% | |
| Point mutations | Sensitivity | 88.9% | 97.2% |
| Specificity | 92.3% | 100% | |
| PPV | 97.0% | 100% | |
| NPV | 75.0% | 92.3% | |
| Accuracy | 89.8% | 97.9% | |
| Insertions/Deletions | Sensitivity | 58.3% | 91.7% |
| Specificity | 100% | 100% | |
| PPV | 100% | 100% | |
| NPV | 44.4% | 80.0% | |
| Accuracy | 68.8% | 93.8% | |
AF: Allele Frequency; PPV: positive predictive value; NPV: negative predictive value.