Table 3. Sensitivity, specificity and accuracy for CLv2 and OLcfDNA panel determined with 0.1% allele frequency mutated reference standard DNA extracted from synthetic plasma samples.
| Results for 0.1% allele frequency reference dilution | |||
|---|---|---|---|
| CLv2 | OLcfDNA | ||
| All 8 hotspot mutations | Sensitivity | 50% | 87.5% |
| Specificity | 93.8% | 100% | |
| PPV | 88.9% | 100% | |
| NPV | 65.2% | 88.9% | |
| Accuracy | 71.9% | 93.8% | |
| Point mutations | Sensitivity | 66.7% | 91.7% |
| Specificity | 91.7% | 100% | |
| PPV | 88.9% | 100% | |
| NPV | 73.3% | 92.3% | |
| Accuracy | 79.2% | 95.8% | |
| Insertions/Deletions | Sensitivity | 0% | 75.0% |
| Specificity | 100% | 100% | |
| PPV | NA | 100% | |
| NPV | 50.0% | 80.0% | |
| Accuracy | 50.0% | 87.5% | |
PPV: positive predictive value; NPV: negative predictive value; NA: not analyzable.