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. 2018 Apr 6;9(26):18607–18626. doi: 10.18632/oncotarget.24719

Table 1. Characteristics of the included studies and Newcastle-Ottawa quality assessment (NOS) evaluation.

Included articles references Subjects characteristics NOS
First Author Journal Year Cancer Type Cases Controls Age Ethnicity Source of Controls NOS 123 NOS [0–9]
Adiguzel M. [12] Indian J Exp Biol 2016 Bone tumors 54 81 Adult Caucasian Population 413 8
Alhopuro P. [13] J Med Genet 2005 Soft tissue sarcoma 68 185 Adult Caucasian Population 413 8
Almeida PSR. [14] Genet Mol Res 2008 Soft tissue sarcoma 100 85 Adult Mixed not specified 213 6
Aoyama T. [15] Cancer Letters 2002 Bone tumors 38 72 Adult Asian Population 313 7
Barnette P. [16] Cancer Epidemiol Biomarkers Prev 2004 Mixed 42 326 Pediat/Young Caucasian Population 323 8
Biason P. [17] Pharmacogenomics J 2012 Bone tumors 130 250 Adult Caucasian Hospital 323 8
Bilbao-Aldaiturriaga N. [18] Pediatr Blood Cancer 2015 Bone tumors 99 387 Pediat/Young Caucasian Hospital 323 8
Chen Y. [19] Tumor Biol 2016 Bone tumors 190 190 Adult Asian Hospital 323 8
Cong Y. [20] Tumor Biol 2015 Bone tumors 203 406 Adult Asian Hospital 323 8
Cui Y. [21] Biomarkers 2016 Bone tumors 251 251 Adult Asian Hospital 323 8
Cui Y. [22] Tumor Biol 2016 Bone tumors 260 260 Adult Asian Hospital 323 8
Dong YZ. [23] Genet Mol Res 2015 Bone tumors 185 201 Adult Asian Hospital 323 8
DuBois SG. [24] Pediatr Blood Cancer 2011 Ewing's sarcoma 135 200 Pediat/Young Caucasian Hospital 213 6
Ergen A. [25] Mol Biol Rep 2011 Bone tumors 50 50 Adult Caucasian not specified 313 7
Feng D. [26] Genet Test Mol Biomarkers 2013 Ewing's sarcoma 308 362 Adult Asian Hospital 323 8
Gloudemans T. [27] Cancer Res 1993 Soft tissue sarcoma 9 26 Adult Caucasian Population 303 6
Grochola LF. [28] Clin Cancer Res 2009 Soft tissue sarcoma 130 497 Adult Caucasian Population 313 7
Grünewald TG. [29] Nat Genet 2015 Ewing's sarcoma 343 251 Adult Caucasian Population 423 9
Guo J. [30] Genet Mol Res 2015 Bone tumors 136 136 Adult Asian Hospital 313 7
He J. [31] Endocr J 2013 Bone tumors 415 431 Adult Asian Hospital 323 8
He J. [32] Endocrine 2014 Bone tumors 415 431 Adult Asian Hospital 323 8
He M. [33] Tumor Biol 2014 Bone tumors 189 195 Adult Asian Hospital 323 8
He ML. [34] Asian Pac J Cancer Prev 2013 Bone tumors 59 63 Adult Asian Hospital 313 7
He Y. [35] Int Orthop 2014 Bone tumors 120 120 Adult Asian Hospital 323 8
Hu GL. [36] Genet Mol Res 2015 Bone tumors 130 130 Adult Asian Hospital 323 8
Hu YS. [37] BMC Cancer 2010 Bone tumors 168 168 Adult Asian Population 423 9
Hu YS. [38] Med Oncol 2011 Bone tumors 168 168 Adult Asian Population 423 9
Hu Z. [39] Genet Test Mol Biomarkers 2015 Bone tumors 368 370 Adult Asian not specified 213 6
Ito M. [40] Clin Cancer Res 2010 Soft tissue sarcoma 155 37 Adult Mixed Hospital 203 5
Jiang C. [41] Med Oncol 2014 Bone tumors 168 216 Adult Asian Hospital 323 8
Kelley MJ. [42] Hum Genet 2014 Chordoma 103 160 Adult Asian Population 413 8
Koshkina NV. [43] J Pediatr Hematol Oncol 2007 Bone tumors 123 510 Pediat/Young Mixed Population 413 8
Le Morvan V. [44] Int J Cancer 2006 Mixed 93 53 Adult Caucasian Population 403 7
Li L. [45] Genet Mol Res 2015 Bone tumors 52 100 Adult Asian Hospital 312 6
Liu Y. [46] DNA Cell Biol 2011 Bone tumors 267 282 Adult Asian Population 313 7
Liu Y. [47] PloSONE 2012 Bone tumors 326 433 Adult Asian Population 423 9
Lu H. [48] Tumor Biol 2015 Bone tumors 388 388 Adult Asian Hospital 323 8
Lu XF. [49] Asian Pac J Cancer Prev 2011 Bone tumors 110 226 Adult Asian Hospital 313 7
Lv H. [50] Mol Med Rep 2014 Bone tumors 103 201 Adult Asian Hospital 213 6
Ma X. [51] Genet Mol Res 2016 Bone tumors 141 282 Adult Asian Hospital 223 7
Martinelli M. [52] Oncotarget 2016 Ewing's sarcoma 100 147 Pediat/Young Caucasian Population 423 9
Mei JW. [99] Int J Clin Exp Pathol 2016 Bone tumors 97 120 Adult Asian Population 313 7
Miao C.[53] Sci Rep 2015 Soft tissue sarcoma 138 131 Adult Asian Hospital 223 7
Mirabello L. [54] Carcinogenesis 2010 Bone tumors 99 1430 Adult Caucasian mixed 323 8
Mirabello L. [55] BMC Cancer 2011 Bone tumors 96 1426 Adult Caucasian mixed 323 8
Nakayama R. [56] Cancer Sci 2008 Mixed 544 1378 Adult Asian mixed 323 8
Naumov VA. [57] Bull Exp Biol Med 2012 Bone tumors 68 96 Adult Caucasian not specified 313 7
Oliveira ID. [58] J Pediatr Hematol Oncol 2007 Bone tumors 80 160 Pediat/Young Mixed Hospital 323 8
Ozger H. [59] Folia Biologica (Praha) 2008 Mixed 56 44 Adult Caucasian Population 403 7
Patino-Garcia A. [60] J Med Genet 2000 Bone tumors 110 111 Pediat/Young Caucasian not specified 323 8
Pillay N. [61] Nat Genet 2012 Chordoma 40 358 Adult Caucasian population 323 8
Postel-Vinay S. [10] Nat Genet 2012 Ewing's sarcoma 401 4352 Adult Caucasian population 423 9
Qi Y. [62] Tumor Biol 2016 Bone tumors 206 206 Adult Asian Hospital 323 8
Qu WR. [63] Genetic Mol Res 2016 Bone tumors 153 252 Adult Asian Hospital 323 8
Ru JY. [64] Int J Clin Exp Pathol 2015 Bone tumors 210 420 Adult Asian Hospital 323 8
Ruza E. [65] J Pediatr Hematol Oncol 2003 Mixed 125 143 Pediat/Young Caucasian not specified 322 7
Saito T. [66] Int J Cancer 2000 Hemangiosarcoma 22 84 Adult Mixed Population 213 6
Salinas-Souza C. [67] Pharmacogenet Genomics 2010 Bone tumors 80 160 Pediat/Young Mixed Hospital 323 8
Savage SA. [68] Cancer Epidemiol Biomarkers Prev 2007 Bone tumors 104 74 Pediat/Young Caucasian Hospital 213 6
Savage SA. [69] Pediatr Blood Cancer 2007 Bone tumors 104 74 Pediat/Young Caucasian Hospital 213 6
Savage SA. [11] Nat Genet 2013 Bone tumors 941 3291 Adult Caucasian Population 423 9
Shi ZW. [70] Cancer Biomark 2016 Bone tumors 174 150 Adult Asian Hospital 313 7
Silva DS. [71] Gene 2012 Ewing's sarcoma 24 200 Adult Mixed Population 323 8
Tang YJ. [72] Medicine 2014 Bone tumors 160 250 Adult Asian Population 423 9
Thurow HS. [73] Mol Biol Rep 2013 Ewing's sarcoma 24 91 Adult Mixed Population 323 8
Tian Q. [74] Eur J Surg Oncol 2013 Bone tumors 133 133 Adult Asian Population 423 9
Tie Z. [75] Int J Clin Exp Pathol 2014 Bone tumors 165 330 Adult Asian Population 423 9
Toffoli G. [76] Clin Cancer Res 2009 Bone tumors 201 250 Adult Caucasian Population 423 9
Walsh KM. [77] Carcinogenesis 2016 Bone tumors 660 6892 Pediat/Young Caucasian Population 423 9
Wang J. [78] DNA Cell Biol 2012 Ewing's sarcoma 158 212 Adult Asian Population 323 8
Wang J. [79] DNA Cell Biol 2013 Bone tumors 106 210 Adult Asian Population 323 8
Wang K. [80] Biomed Rep 2014 Chordoma 65 65 Adult Asian Population 313 7
Wang K. [81] Tumor Biol 2016 Bone tumors 126 168 Adult Asian Hospital 323 8
Wang W. [82] DNA Cell Biol 2011 Bone tumors 205 216 Adult Asian Hospital 323 8
Wang W. [83] Genet Test Mol Biomarkers 2011 Bone tumors 205 215 Adult Asian Hospital 323 8
Wang Z. [84] Tumor Biol 2014 Bone tumors 330 342 Adult Asian Population 423 9
Wu Y. [85] Tumor Biol 2015 Bone tumors 124 136 Adult Asian Hospital 323 8
Wu Z. [86] Int J Mol Sci 2013 Chordoma 65 120 Adult Asian not specified 313 7
Xin DJ. [87] Int J Clin Exp Pathol 2015 Bone tumors 90 100 Adult Asian Population 413 8
Xu H. [88] Med Sci Monit 2016 Bone tumors 279 286 Pediat/Young Asian Hospital 323 8
Xu S. [89] DNA Cell Biol 2014 Bone tumors 202 216 Adult Asian Population 423 9
Yang L. [90] Int J Clin Exp Pathol 2015 Bone tumors 152 304 Adult Asian Population 423 9
Yang S. [91] Genet Test Mol Biomarkers 2012 Ewing's sarcoma 223 302 Adult Asian Population 423 9
Yang W. [92] Med Oncol 2014 Bone tumors 118 126 Adult Asian not specified 323 8
Zhang G. [93] Genet Mol Res 2015 Bone tumors 180 360 Adult Asian Population 423 9
Zhang HF. [94] Genet Mol Res 2015 Bone tumors 182 182 Adult Asian Population 423 9
Zhang N. [95] Onco Targets Ther 2016 Bone tumors 276 286 Adult Asian Hospital 323 8
Zhang Y. [96] Tumor Biol 2014 Bone tumors 610 610 Adult Asian Population 423 9
Zhao J. [97] BioMed Res Int 2014 Bone tumors 247 428 Adult Asian Population 423 9
Zhi LQ. [98] Tumor Biol 2014 Bone tumors 212 240 Adult Asian Hospital 323 8

NOS: Newcastle-Ottawa quality assessment scale evaluation (0-9). NOS1: selection of the study groups (0-4); NOS2: comparability of the groups (0-2); NOS3: ascertainment of the exposure or outcome (0-3).