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. 2018 Apr;59(5):2154–2166. doi: 10.1167/iovs.17-23282

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Copyright 2018 The Authors

This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.

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Fibronectin, collagen-1, and collagen-4 expression in the TM of B6;129S1-Bambi^tm1Jian/J mice treated with Ad5.TGFβ2 and Ad5.Cre. Mice were injected with Ad5.Null (2.5 × 10⁷ pfu), Ad5.TGFβ2 (2.5 × 10⁷ pfu), or Ad5.Cre (2.5 × 10⁷ pfu) intravitreally in one eye of each animal and the contralateral uninjected eyes were used as controls. Eyes were harvested 11 days after injection and analyzed for fibronectin, collagen-1, and collagen-4 expression by immunohistochemistry. Ad5.Cre (n = 15) and Ad5.TGFβ2 (n = 9) increased fibronectin, collagen-1, and collagen-4 expression in the TM compared to Ad5.Null (n = 7).