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. 2018 Apr 3;9(25):17349–17367. doi: 10.18632/oncotarget.24693

Figure 9. Blocking of SOD3 with antiSOD3 inhibits in vivo angiogenesis in the mouse Matrigel plug assay.

Figure 9

(A) Inhibition of in vivo angiogenesis. Paraffin sections of Matrigel plugs with different conditions (IgG, IgG+FGF2 or antiSOD3+FGF2) were stained with anti-endomucin (endothelial marker) and DAPI (nuclear marker). Representative pictures at 10X magnification are showed. Scale bars represent 100 μm. (B) Endomucin positive areas were quantified using ImageJ software, relativized to total DAPI signal, and all data were expressed as means ± SD of 3 plugs (IgG) or 4 plugs (rest of conditions) and normalized to the IgG+FGF2 condition (100%). Symbols indicate significant differences between IgG+FGF2 and rest of conditions (**p<0.01, ***p<0.005) using a Student’s t test.

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