Table 3. Performance of single markers for discriminating CCA and PSC.
| Biomarker(s) | Cut-off | Sensitivity % (95% CI) | Specificity % (95% CI) | AUC (95% CI) |
|---|---|---|---|---|
| CA19-9 (U/mL) | > 37.0 | 74.2 (62.0–84.2) | 74.2 (61.5–84.5) | 0.789 (0.71–0.87) |
| LRG1 (μg/mL) | > 57.5* | 4.5 (0.9–12.1) | 91.9 (82.2–97.3) | 0.562 (0.461–0.662) |
| IL6 (pg/mL) | > 48.4* | 80.3 (68.7–89.1) | 17.7 (9.2–29.5) | 0.543 (0.443–0.643) |
| PKM2 (ng/mL) | > 2.2 | 75.8 (63.6–85.5) | 82.3 (70.5–90.8) | 0.839 (0.768–0.91) |
| CYFRA21.1 (ng/mL) | > 4.0 | 65.2 (52.4–76.5) | 75.8 (63.3–85.8) | 0.732 (0.645–0.819) |
| MUC5AC (ng/mL) | > 0.67 | 60.6 (47.8–72.4) | 82.3 (70.5–90.8) | 0.72 (0.631–0.809) |
CI = confidence interval.*Cut-offs used in previous study [21].