Table 5. Correlation between PIK3CA mutation status and clinicopathological factors in pre- and postmenopausal women.
| Premenopausal | Postmenopausal | |||||
|---|---|---|---|---|---|---|
| Wild-type (n = 31) |
Mutant (n = 29) |
P | Wild-type (n = 73) |
Mutant (n = 71) |
P | |
| Age (years), mean ± SD (range) |
43.2 ± 5.9 (27–52) |
45.4 ± 5.1 (35–56) |
0.17 | 62.0 ± 8.2 (42–80) |
63.8 ± 8.2 (47–84) |
0.18 |
| BMI, mean ± SD (range) |
21.8 ± 4.1 (15.2–32.9) |
21.8 ± 3.4 (16.7–32) |
0.63 | 24.6 ± 4.4 (14–38.4) |
23.8 ± 4.1 (14.2–40.9) |
0.38 |
| Tumor size (T), median (range) |
1 (1–2) | 1 (1–3) | 0.56 | 1 (1–3) | 1 (1–3) | 0.34 |
| No. of positive lymph nodes, median (range) |
0 (0–23) | 0 (0–20) | 0.30 | 0 (0–10) | 0 (0–10) | 0.90 |
| Tumor grade, median (range) mean ± SD |
2 (1–3) 1.7 ± 0.6 |
2 (1–3) 2.0 ± 0.6 |
0.041* | 2 (1–3) 2.0 ± 0.5 |
2 (1–3) 1.8 ± 0.6 |
0.051 |
| Ki67 LI (%), median (range) mean ± SD |
10.1 (0–62.7) 13.3 ± 13.6 |
12.2 (1.2–61.3) 15.1 ± 13.1 |
0.46 | 10.3 (2.0–52.7) 13.7 ± 10.3 |
7.5 (0.1–35.3) 10.2 ± 8.1 |
0.03* |
| ER (%), median (range) mean ± SD |
90 (40–100) 83.2 ± 18.9 |
80 (10–100) 68.6 ± 29.1 |
0.025* | 90 (10–100) 79.9 ± 24.1 |
90 (20–100) 83.1 ± 20.3 |
0.40 |
| PgR (%), median (range) mean ± SD |
90 (0–100) 65.5 ± 37.0 |
80 (0–100) 62.8 ± 34.7 |
0.44 | 10 (0–100) 27.7 ± 32.1 |
20 (0–100) 30.9 ± 31.1 |
0.37 |
| AR (%), median (range) mean ± SD |
1.0 (0–80) 17.4 ± 23.4 |
20 (1–90) 28.0 ± 26.8 |
0.047* | 30 (0–95) 33.0 ± 28.9 |
35 (0–100) 43.6 ± 33.8 |
0.065 |
| VDR (%), median (range) mean ± SD |
10 (0–95) 15.4 ± 17.9 |
10 (0–70) 16.2 ± 17.9 |
0.91 | 10 (0–80) 15.7 ± 16.4 |
20 (0–50) 18.0 ± 13.1 |
0.13 |
| pAKT (score), median (range) mean ± SD |
120 (0–300) 146.5 ± 93.4 |
100 (0–230) 105.5 ± 76.9 |
0.14 | 100 (0–300) 110.2 ± 79.1 |
70 (0–290) 75.5 ± 65.8 |
0.0049* |
| pER (%), median (range) mean ± SD |
20 (0–90) 25.0 ± 21.3 |
20 (1–95) 23.1± 21.5 |
0.74 | 15 (0–90) 17.8 ± 17.8 |
20 (0–90) 23.4 ± 18.0 |
0.018* |
LI: labeling index; pAKT: AKT phospho-Ser473; pER: ERα phospho-Ser167.
*P < 0.05 is considered significant.